Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naïve Schizophrenia

Dados Bibliográficos

ID15519635
AutoresYuxuan Wu (0000-0002-9155-9883, Soochow University), Xiangdong Du (0000-0002-9263-0178, Soochow University, autor correspondente), Ruchang Yang (0000-0002-7256-5380, Soochow University), Yan Yue (0000-0002-4904-0711, Soochow University), Ruijie Peng (0009-0001-5013-0466, Soochow University), Siqi Wu (0000-0001-8234-6600, North China University of Science and Technology), Haitao Wang (0000-0001-9900-8528, North China University of Science and Technology), Yue Zhou (0009-0009-2070-9715, Xuzhou Medical College), Xiaojia Fang (Xuzhou Medical College), Nian Yuan (Soochow University), Ronghua Li (0000-0002-3105-5325, Soochow University), Jun Zhang (0000-0003-1706-1611, Soochow University), Siyun Zou (Soochow University), Xueli Zhao (0009-0003-9278-8199, Soochow University), Xiaoli Lyu (0000-0001-7196-4841, Soochow University), Zhe Li (0000-0002-2003-0827, Soochow University), Xiaobin Zhang (0000-0001-9129-7425, Soochow University, autor correspondente), Xiangyang Zhang (0000-0003-3326-382X, Soochow University)
Ano2022
Volume13
Páginas911384-911384
Data de publicação2022-06-09
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.911384
PMID35757201
OpenAlexW4282051943
IdiomaEN
Referências citadas6

Previous studies have revealed that brain-derived neurotrophic factor (BDNF) levels are inversely associated with the severity of depressive symptoms. In addition, serum BDNF levels tend to increase with improvement in depressive symptoms. There is also evidence that BDNF has a possible role in the pathophysiology of schizophrenia. Therefore, the purpose of this study was to determine whether BDNF levels correlated with depressive symptoms in patients with first-episode and drug-naïve (FEDN) schizophrenia. In this study, 90 patients with FEDN schizophrenia and 60 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the 17-item Hamilton Depression Scale (HAMD-17) were used to gage psychopathological and depressive symptoms, respectively. All participants had their BDNF levels measured using a sandwich enzyme-linked immunosorbent test. Serum BDNF levels were lower in patients with FEDN schizophrenia compared with healthy controls. Moreover, patients with depressive symptoms exhibited a higher PANSS total score and a higher general psychopathology score than those without depressive symptoms ( p p p p > 0.05). In conclusion, BDNF levels were shown to be higher in the serum of patients with FEDN schizophrenia with depressive symptoms than in those without. Additionally, low levels of serum BDNF may contribute to the positive symptoms of FEDN schizophrenia but not to depressive symptoms

Association (psychology · Brain-derived neurotrophic factor · Cognition · Depressive symptoms · Drug · Drug-naïve · Neurotrophic factors · Psychiatry · Psychotherapist · Receptor · Risk factor · Schizophrenia (object-oriented programming · Clinical Psychology · Medicine · Nerve injury and regeneration · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Internal Medicine · Oncology