The alternations of nucleus accumbent in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment
Bibliographic Data
| ID | 15519662 |
|---|---|
| Authors | Yuanjun Xie (0000-0002-9787-8244, Xinyang College of Agriculture and Forestry, corresponding author), Yun Cai (0000-0002-5402-8143, Army Medical University), Muzhen Guan (0000-0002-9756-8713, Xi'an Medical University), Zhongheng Wang (Xijing Hospital), Zhujing Ma (Air Force Medical University), Peng Fang (0000-0002-6495-7317, Air Force Medical University, corresponding author), Huaning Wang (0000-0003-1981-4293, Xijing Hospital) |
| Year | 2022 |
| Volume | 13 |
| Pages | 971105-971105 |
| Publication date | 2022-09-06 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.971105 |
| PMID | 36147981 |
| OpenAlex | W4294724284 |
| Language | EN |
| Citations received | 1 |
| References cited | 75 |
Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce the severity of auditory verbal hallucinations (AVH) and induce beneficial functional and structural alternations of the brain in schizophrenia patients with AVH. The nucleus accumbens (NAcc) as an important component of the ventral striatum is implicated with the pathology in AVH. However, the induced characteristic patterns of NAcc by low-frequency rTMS in schizophrenia with AVH are seldom explored. We investigated the functional and structural characteristic patterns of NAcc by using seed-based functional connectivity (FC) analysis and gray matter volume (GMV) measurement in schizophrenia patients with AVH during 1 Hz rTMS treatment. Although low-frequency rTMS treatment did not affect the volumetric changes of NAcc, the abnormal FC patterns of NAcc, including increased FC of NAcc with the temporal lobes and decreased FC of NAcc with the frontal cortices in the pretreatment patients compared to healthy controls, were normalized or reversed after treatment. These FC changes were associated with improvements in clinical symptoms and neurocognitive functions. Our findings may extend our understanding of the NAcc in the pathology of schizophrenia with AVH and might be a biomarker of clinical effect for low-frequency rTMS treatment in schizophrenia
Audiology · Cognition · Dopamine · Neurocognitive · Nucleus accumbens · Psychiatry · Schizophrenia (object-oriented programming · Stimulation · Striatum · Transcranial magnetic stimulation · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0,33 |
| Citation span | 2023 - 2023 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |