Association between interleukin-27 and suicidal ideation
A Mendelian randomization analysis and peripheral blood experimental study
Bibliographic Data
| ID | 15519682 |
|---|---|
| Authors | Xiwen Hu (0000-0003-3995-7670, Hangzhou Seventh Peoples Hospital), Xiaowen Yin (0009-0004-1594-305X, Hangzhou Seventh Peoples Hospital), Shengdong Wang (0000-0002-8231-1341, Hangzhou Seventh Peoples Hospital), Chunyan Zhu (0000-0002-3434-2581, Hangzhou Seventh Peoples Hospital), Xuan Ju (Hangzhou Seventh Peoples Hospital), Zhonglin Tan (Hangzhou Seventh Peoples Hospital, corresponding author), Lingna Lu (Tongde Hospital of Zhejiang Province, corresponding author) |
| Year | 2026 |
| Volume | 16 |
| Pages | 1678780-1678780 |
| Publication date | 2026-01-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1678780 |
| PMID | 41561993 |
| OpenAlex | W7118196676 |
| Language | EN |
| References cited | 43 |
There are genetic associations between IL-27 and suicidal ideation, which is biologically corroborated by elevated peripheral IL-27 levels in high-risk suicidal individuals, highlighting its potential as a clinically viable biomarker for assessing suicidal risk in depressive patients
Association (psychology · Biomarker · Depressive symptoms · Genetic association · Major depressive disorder · Mendelian randomization · Peripheral · Peripheral blood · Suicidal behavior · Suicidal ideation · Stress Responses and Cortisol · Suicide and Self-Harm Studies · Tryptophan and brain disorders
The Bidirectional Relationship of Depression and Inflammation
Peripheral cytokine and chemokine alterations in depression
Investigation of peripheral inflammatory biomarkers in association with suicide risk in major depressive disorder
Altered Levels of Plasma Inflammatory Cytokines and White Matter Integrity in Bipolar Disorder Patients With Suicide Attempts
Relationship between serum inflammatory cytokines and suicide risk in patients with major depressive disorder
High Serum Levels of IL-6 Are Associated with Suicide Attempt but Not with High Lethality Suicide Attempts
| Citation velocity | historical |
|---|---|
| Highly cited | No |