Impulsive Action and Impulsive Choice Are Differentially Expressed in Rats Depending on the Age at Exposure to a Gambling Task
Bibliographic Data
| ID | 15519723 |
|---|---|
| Authors | Bo Ram Cho (0000-0002-6582-1390, Yonsei University), Myung Ji Kwak (0000-0001-7837-9936, Yonsei University), Wha Young Kim (0000-0003-1744-7012, Yonsei University, corresponding author), Jeong‐Hoon Kim (0000-0002-2397-2668, corresponding author), Jeong-hoon Kim (0000-0001-7095-3729, Yonsei University, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 503-503 |
| Publication date | 2018-10-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00503 |
| PMID | 30386266 |
| OpenAlex | W2897774258 |
| Language | EN |
| Citations received | 2 |
| References cited | 28 |
Impulsivity is considered an important feature associated with the development of numerous psychiatric disorders, including addictions. In the behavioral approach, impulsivity can be broadly divided into two distinct subtypes: impulsive action and choice. In the present study, we used a rodent version of the gambling task (rGT) to examine how impulsive action and impulsive choice are differentially influenced by difference in age at exposure (i.e., late adolescents/young adults vs. mature adults) to rGT. Rats were trained in a touch-screen chamber to learn the relationships between 4 light signals on the window of the screen and accompanying reward outcomes or punishments associated with different magnitudes and probabilities. Depending on their stabilized pattern of preference when allowed free choice, rats were categorized into risk-averse or risk-seeking group. While undergoing a series of experimental schemes, including extinction, re-acquisition, and acute cocaine injection, rats were re-tested for their premature response during inter-trial interval and choice preference toward the 4 different windows in rGT. Notably, rats exposed early, compared with those exposed late, to rGT showed increased impulsive action, particularly during re-acquisition period, in all sub-groups. In contrast, rats exposed late, compared with those exposed early, to rGT showed increased impulsive choice after acute cocaine injection, but these results were only obtained in a sub-group pre-categorized as high impulsive and risk-averse. These results suggest that different aspects of impulsivity can be differentially expressed during decision-making, and differentially influenced by the age at exposure to a gambling task
Action (physics · Addiction · Analysis of variance · Audiology · Biology · Cognition · Conditioned place preference · Developmental psychology · Extinction (optical mineralogy · Impulsivity · Iowa gambling task · Preference · Psychiatry · Medicine · Neuroendocrine regulation and behavior · Neurotransmitter Receptor Influence on Behavior · Psychology · Stress Responses and Cortisol · Internal Medicine · Physiology
| Citations per year | 0.4 |
|---|---|
| Citation span | 2021 - 2022 (2) |
| Highly cited | No |