Combined Norepinephrine/Serotonergic Reuptake Inhibition

Effects on Maternal Behavior, Aggression, and Oxytocin in the Rat

Bibliographic Data

ID15519928
AuthorsElizabeth Cox (0000-0002-0984-2891, University of North Carolina at Chapel Hill, corresponding author), Thomas M Jarrett (0000-0002-0753-6129, University of North Carolina at Chapel Hill), Matthew S Mcmurray (0000-0002-1898-2933, University of North Carolina at Chapel Hill), Kevin Greenhill (University of North Carolina at Chapel Hill), Vivian E Hofler (University of North Carolina at Chapel Hill), Sarah K Williams (0000-0002-9898-5420, University of North Carolina at Chapel Hill), Paul Joyner (University of Connecticut), Christopher Middleton (Augusta University), Cheryl H Walker (University of North Carolina at Chapel Hill), Josephine M Johns (University of North Carolina at Chapel Hill)
Year2011
Volume2
Pages34-34
Publication date2011-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2011.00034
PMID21713063
PMCIDPMC3114092
OpenAlexW2099527315
LanguageEN
References cited2

Amitriptyline and desipramine differentially reduced MB, and at higher doses reduced aggressive behavior. Hippocampal oxytocin levels were lower after treatment with either drug but were not correlated with specific behavioral effects. These results, in combination with previous findings following gestational treatment with other selective neurotransmitter reuptake inhibitors, highlight the diverse effects of multiple monoamine systems thought to be involved in maternal care

Aggression · Antidepressant · Dopamine · Hippocampus · Norepinephrine · Norepinephrine transporter · Oxytocin · Psychiatry · Reuptake · Reuptake inhibitor · Serotonergic · Serotonin · Attachment and Relationship Dynamics · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Psychology · Internal Medicine · Pharmacology

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