The Adcyap1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population

Datos Bibliográficos

ID15519983
AutoresLi Wang (0000-0002-3460-2080, Chinese Academy of Sciences), Jingyi Zhang (0000-0002-3147-8838, Chinese Academy of Sciences), Gen Li (0000-0003-4910-0523, University of Chinese Academy of Sciences), Chengqi Cao (0000-0002-0320-7395, Institute of Psychology, Chinese Academy of Sciences), Ruojiao Fang (Chinese Academy of Sciences), Ping Liu (0000-0002-8713-1999), Shu Luo (0000-0003-2911-4434), Guangyi Zhao (University of Chinese Academy of Sciences), Yingqian Zhang (0000-0001-6158-4992, Institute of Psychology, Chinese Academy of Sciences), Kunlin Zhang (0000-0003-0284-1666, Institute of Psychology, Chinese Academy of Sciences, autor de correspondencia)
Año2021
Volumen12
Páginas665599-665599
Fecha de publicación2021-06-07
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Psychiatry (JOURNAL)
Identificadores de la revistaISSN: 1664-0640 • E-ISSN: 1664-0640
EditorialFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.665599
PMID34163384
OpenAlexW3207435179
IdiomaEN
Referencias citadas59

The adenylate cyclase activating polypeptide 1 (pituitary) receptor ( ADCYAP1R1 ) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1 , rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects ( P > 0.05). The G × G ADCYAP1R1 - FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = -1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1 - CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = -4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions

Biology · FKBP5 · Gene · Genotype · Glucocorticoid receptor · Polymorphism (computer science · Posttraumatic stress · Psychiatry · Receptor · Single-nucleotide polymorphism · Birth, Development, and Health · Child Abuse and Trauma · Clinical Psychology · Medicine · Psychology · Stress Responses and Cortisol · Genetics · Internal Medicine