Evidence for Schizophrenia-Specific Pathophysiology of Nicotine Dependence
Bibliographic Data
| ID | 15520072 |
|---|---|
| Authors | Heather Burrell Ward (0000-0003-2901-8004, Beth Israel Deaconess Medical Center, corresponding author), Adam Beermann (Beth Israel Deaconess Medical Center), Uzma Nawaz (Beth Israel Deaconess Medical Center), Mark A Halko (0000-0002-7427-0789, Harvard University), Amy C Janes (0000-0002-3749-5006, Harvard University), Lauren V Moran (0000-0002-5185-1767, Harvard University), Roscoe O Brady (0000-0002-2692-6755, Harvard University) |
| Year | 2022 |
| Volume | 13 |
| Pages | 804055-804055 |
| Publication date | 2022-01-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.804055 |
| PMID | 35153877 |
| OpenAlex | W4225365117 |
| Language | EN |
| Citations received | 2 |
| References cited | 44 |
Tobacco use is the top preventable cause of early mortality in schizophrenia. Over 60% of people with schizophrenia smoke, three times the general prevalence. The biological basis of this increased risk is not understood, and existing interventions do not target schizophrenia-specific pathology. We therefore used a connectome-wide analysis to identify schizophrenia-specific circuits of nicotine addiction. We reanalyzed data from two studies: In Cohort 1, 35 smokers (18 schizophrenia, 17 control) underwent resting-state fMRI and clinical characterization. A multivariate pattern analysis of whole-connectome data was used to identify the strongest links between cigarette use and functional connectivity. In Cohort 2, 12 schizophrenia participants and 12 controls were enrolled in a randomized, controlled crossover study of nicotine patch with resting-state fMRI. We correlated change in network functional connectivity with nicotine dose. In Cohort 1, the strongest ( p R = -0.50; 95% CI -0.75 to -0.12, p p < 0.05). Nicotine administration normalized DMN hyperconnectivity in schizophrenia. We here provide direct evidence that the biological basis of nicotine dependence is different in schizophrenia and in non-schizophrenia populations. Our results suggest the high prevalence of nicotine use in schizophrenia may be an attempt to correct a network deficit known to interfere with cognition
Nicotine · Nicotine dependence · Pathophysiology · Psychiatry · Schizophrenia (object-oriented programming · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Neuroscience · Nicotinic Acetylcholine Receptors Study · Psychology · Tryptophan and brain disorders · Internal Medicine
Nicotine Dependence and Psychiatric Disorders in the United States
Dpabi
Premature Mortality Among Adults With Schizophrenia in the United States
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Current Cigarette Smoking Among Adults — United States, 2016
Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
| Citations per year | 2 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |