Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice
Bibliographic Data
| ID | 15520076 |
|---|---|
| Authors | Florence Allain (0000-0002-0126-3916, Douglas Mental Health University Institute), Aliza T Ehrlich (0000-0001-7507-1100, Douglas Mental Health University Institute), Michael McNicholas (0000-0002-6920-9924, Douglas Mental Health University Institute), Florence Gross (Douglas Mental Health University Institute), Weiya Ma (Douglas Mental Health University Institute), Brigitte L Kieffer (0000-0002-8809-8334, Inserm), Emmanuel Darcq (0000-0002-8377-8015, Douglas Mental Health University Institute, corresponding author) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1186397-1186397 |
| Publication date | 2023-05-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1186397 |
| PMID | 37287667 |
| OpenAlex | W4378084179 |
| Language | EN |
| Citations received | 1 |
| References cited | 22 |
These findings suggest that tianeptine's opioid-like effects require MOR and that chronic use could lead to tolerance
Agonist · Analgesic · Antidepressant · Hippocampus · Opioid · Receptor · Tianeptine · μ-opioid receptor · Chemistry · Medicine · Neuropeptides and Animal Physiology · Neuroscience · Neuroscience and Neuropharmacology Research · Psychology · Receptor Mechanisms and Signaling · Internal Medicine · Pharmacology
| Citations per year | 1 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |