MTHFR C677T is not associated with autism spectrum disorder in a Mexican cohort
Bibliographic Data
| ID | 15520449 |
|---|---|
| Authors | Mirna Edith Morales-Marín (0000-0001-5460-6284, National Institute of Genomic Medicine), Omar Náfate-López (Hospitales Regionales de Alta Especialidad), Amalia Guadalupe Gómez Cotero (0000-0001-5334-2707, Instituto Politécnico Nacional), Amalia Guadalupe Gómez-Cotero, Miguel A Cid-Soto (0000-0001-9975-984X, National Institute of Genomic Medicine), Humberto Nicolini (0000-0003-0390-8252, National Institute of Genomic Medicine, corresponding author), Xóchitl Helga Castro-Martínez (National Institute of Genomic Medicine, corresponding author) |
| Year | 2025 |
| Volume | 16 |
| Pages | 1452940-1452940 |
| Publication date | 2025-11-17 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1452940 |
| PMID | 41334077 |
| OpenAlex | W4416297681 |
| Language | EN |
| References cited | 27 |
Using genetic approaches to study autism spectrum disorder (ASD) is essential to understanding the etiology of the condition. The C677T variant has emerged as a risk factor, and here we present the first association study of this variant in a Mexican population with ASD. Our objective was to assess the variant MTHFR C677T (rs1801133) in a group of Mexican patients with ASD through a case-control association analysis. We found no significant association of MTHFR C677T and ASD, with no rate differences between cases and controls (C vs T: odds ratio = 0.9698, 95% confidence interval = 0.7773-1.21, P = 0.7858). Results of this and other studies evaluating the link between ASD and this variant have been controversial. Our findings suggest that other ancestry-related factors may play a role
Association (psychology · Autism · Autism spectrum disorder · Cohort · Confidence interval · Etiology · Methylenetetrahydrofolate reductase · Odds ratio · Autism Spectrum Disorder Research · Folate and B Vitamins Research · Genetics and Neurodevelopmental Disorders
| Highly cited | No |
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