Effect of online aerobic exercise training in patients with bipolar depression
Protocol of a randomized clinical trial
Bibliographic Data
| ID | 15520481 |
|---|---|
| Authors | Xueqian Wang (0000-0002-3189-361X, Chongqing Medical University), Huirong Luo (0000-0002-2741-2238, Chongqing Medical University), Yinlin Zhang (The Affiliated Yongchuan Hospital of Chongqing Medical University), Maolin Mao (The Affiliated Yongchuan Hospital of Chongqing Medical University), Yulin Lu (0009-0006-4648-2131), Zheng Zhang (0000-0002-0389-1844, The Affiliated Yongchuan Hospital of Chongqing Medical University), Chunfeng Jiang (First People's Hospital of Chongqing), Qinghua Luo (0000-0002-0518-0990, The Affiliated Yongchuan Hospital of Chongqing Medical University, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 1011978-1011978 |
| Publication date | 2022-11-09 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.1011978 |
| OpenAlex | W4308719633 |
| Language | EN |
| References cited | 59 |
Introduction Bipolar disorder (BD) is a common and debilitating mental illness that affects about 400 million people worldwide, decreasing their functionality and quality of life. Medication and psychotherapy are recommended for treatment of BD, while some evidence indicates that exercise could improve the clinical outcome of BD. This study aims to investigate whether exercise intervention could reduce the mood symptoms and inflammation level of BD. Methods This is a longitudinal, interventional, randomized, and single-blind trial. We plan to recruit 94 patients diagnosed with BD in depression episode. Patients will be randomly assigned to treatment as usual + aerobic exercise group (intervention group) and treatment as usual (TAU) only group, at a ratio of 1:1. The intervention group will undergo 40-min aerobic exercise training twice a week for eight weeks. The primary outcome of this study is the mean change of Hamilton Depression Rating Scale 17 (HAMD 17) scores from baseline to week 8. The Young Manic Rating Scale (YMRS), Self-Rating Depression Scale (SDS), and Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels will also be measured. The measurements will be performed at baseline, immediately after intervention and two months after intervention. Discussion Aerobic exercise training + treatment is expected to bring more benefits to BD patients than TAU only. This trial might provide stronger evidence of physical exercise efficacy for BD treatment. Clinical trial registration This study was approved by the Chinese Clinical Trial Registry (Registration Code: ChiCTR2200057159). Registered on 1 March 2022
Aerobic exercise · Anxiety · Bipolar disorder · Clinical trial · Depression (economics · Hamd · Hamilton Rating Scale for Depression · Major depressive disorder · Mood · Physical therapy · Political science · Psychiatry · Quality of life (healthcare · Randomized controlled trial · Rating scale · Bipolar Disorder and Treatment · Electroconvulsive Therapy Studies · History and International Relations · Latin American socio-political dynamics · Medicine · Politics and Society in Latin America · Psychology · Tryptophan and brain disorders · Internal Medicine
Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative
Bipolar disorder
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder
EPA guidance on physical activity as a treatment for severe mental illness
Estimating the true global burden of mental illness
A Rating Scale for Mania
Exercise training increases size of hippocampus and improves memory
Exercise for depression
Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women
A Rating Scale for Depression
| Citation velocity | historical |
|---|---|
| Highly cited | No |