Systematic Review of Gut Microbiota and Major Depression

Datos Bibliográficos

ID15520488
AutoresStephanie Cheung (0000-0002-2092-7001, Columbia University), Stephanie G Cheung, Ariel Goldenthal (Columbia University), Ariel R Goldenthal, Anne‐Catrin Uhlemann (0000-0002-9798-4768, Columbia University), Anne-Catrin Uhlemann, J John Mann (0000-0002-0265-6586, New York Psychoanalytic Society and Institute), Jeffrey M Miller (0000-0002-2206-9311, New York State Psychiatric Institute), M Elizabeth Sublette (0000-0001-7378-4262, Columbia University, autor de correspondencia)
Año2019
Volumen10
Páginas34-34
Fecha de publicación2019-02-11
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Psychiatry (JOURNAL)
Identificadores de la revistaISSN: 1664-0640 • E-ISSN: 1664-0640
EditorialFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2019.00034
PMID30804820
OpenAlexW2912729292
IdiomaEN
Citas recibidas20
Referencias citadas146

Background: Recently discovered relationships between the gastrointestinal microbiome and the brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies have examined the gut microbiome in healthy and affected individuals. We systematically reviewed existing studies comparing gut microbial composition in MDD and healthy volunteers. Methods: A PubMed literature search combined the terms "depression," "depressive disorder," "stool," "fecal," "gut," and "microbiome" to identify human case-control studies that investigated relationships between MDD and microbiota quantified from stool. We evaluated the resulting studies, focusing on bacterial taxa that were different between MDD and healthy controls. Results: Six eligible studies were found in which 50 taxa exhibited differences ( p Bacteroidetes, Firmicutes, Actinobacteria, Fusobacteria , and Protobacteria -were represented; however, divergent results occurred across studies for all phyla. The largest number of differentiating taxa were within phylum Firmicutes , in which nine families and 12 genera differentiated the diagnostic groups. The majority of these families and genera were found to be statistically different between the two groups in two identified studies. Family Lachnospiraceae differentiated the diagnostic groups in four studies (with an even split in directionality). Across all five phyla, nine genera were higher in MDD ( Anaerostipes, Blautia, Clostridium, Klebsiella, Lachnospiraceae incertae sedis, Parabacteroides, Parasutterella, Phascolarctobacterium , and Streptococcus ), six were lower ( Bifidobacterium, Dialister, Escherichia/Shigella, Faecalibacterium , and Ruminococcus ), and six were divergent ( Alistipes, Bacteroides, Megamonas, Oscillibacter, Prevotella , and Roseburia ). We highlight mechanisms and products of bacterial metabolism as they may relate to the etiology of depression. Conclusions: No consensus has emerged from existing human studies of depression and gut microbiome concerning which bacterial taxa are most relevant to depression. This may in part be due to differences in study design. Given that bacterial functions are conserved across taxonomic groups, we propose that studying microbial functioning may be more productive than a purely taxonomic approach to understanding the gut microbiome in depression

Bacteroides · Bacteroidetes · Bioinformatics · Biology · Firmicutes · Fusobacteria · Gut flora · Lachnospiraceae · Major depressive disorder · Microbiome · Prevotella · Ruminococcus · Diet and metabolism studies · Gastrointestinal motility and disorders · Gut microbiota and health · Genetics · Immunology