Levels of neuroactive steroids are elevated in those who develop first-onset depression early in pregnancy

Bibliographic Data

ID15520495
AuthorsElizabeth Wenzel (0000-0002-7732-608X, University of Illinois Chicago, corresponding author), Elizabeth S Wenzel, Jordan C Barone (0000-0002-5999-0921, University of Illinois Chicago), Tory Eisenlohr-Moul (0000-0002-9231-3105, University of Illinois Chicago), Tory A Eisenlohr-Moul, Suzanne Alvernaz (0000-0002-8370-5537, University of Illinois Chicago), Beatriz Peñalver Bernabé (0000-0002-4547-4248, University of Illinois Chicago), Luca Spiro Santovito (0009-0004-0807-3893, University of Illinois Chicago), Ibrahim M M Gdyana (University of Illinois Chicago), Graziano Pinna (0000-0001-7541-4855, University of Chicago), Pauline M Maki (0000-0002-8443-3430, University of Illinois Chicago)
Year2025
Volume16
Pages1557560-1557560
Publication date2025-05-08
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1557560
PMID40405882
OpenAlexW4410215532
LanguageEN
References cited41

These results suggest differing NAS-related mechanisms of pathogenesis across clinical phenotypes based on pre-pregnancy history of MDD and timing of PND onset. Future research should account for these factors when investigating NAS and PND

Allopregnanolone · Biology · Depression (economics · Economics · Neuroactive steroid · Pregnancy · Psychiatry · Birth, Development, and Health · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroendocrine regulation and behavior · Psychology · Internal Medicine

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