Kappa-Opioid Receptor Signaling in the Striatum as a Potential Modulator of Dopamine Transmission in Cocaine Dependence
Bibliographic Data
| ID | 15520554 |
|---|---|
| Authors | Pierre Trifilieff (0000-0002-7893-9697, New York State Psychiatric Institute, corresponding author), Diana Martinez (0000-0003-0982-4092, Columbia University) |
| Year | 2013 |
| Volume | 4 |
| Pages | 44-44 |
| Publication date | 2013-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2013.00044 |
| PMID | 23760592 |
| PMCID | PMC3669800 |
| OpenAlex | W2169943058 |
| Language | EN |
| Citations received | 1 |
| References cited | 9 |
Cocaine addiction is accompanied by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum. These alterations in dopamine transmission have clinical relevance, and have been shown to correlate with cocaine-seeking behavior and response to treatment for cocaine dependence. However, the mechanisms contributing to the hypodopaminergic state in cocaine addiction remain unknown. Here we review the positron emission tomography (PET) imaging studies showing alterations in D2 receptor binding potential and dopamine transmission in cocaine abusers and their significance in cocaine-seeking behavior. Based on animal and human studies, we propose that the kappa receptor/dynorphin system, because of its impact on dopamine transmission and upregulation following cocaine exposure, could contribute to the hypodopaminergic state reported in cocaine addiction, and could thus be a relevant target for treatment development
Addiction · Central nervous system · Cocaine dependence · Dopamine · Dopamine receptor · Dopamine receptor D2 · Dopamine receptor D3 · Dopamine Uptake Inhibitors · Dopaminergic · Dynorphin · Neurotransmitter · Opioid · Opioid peptide · Receptor · Striatum · κ-opioid receptor · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Pharmacological Receptor Mechanisms and Effects · Psychology · Receptor Mechanisms and Signaling · Internal Medicine · Pharmacology
| Citations per year | 0.08 |
|---|---|
| Citation span | 2014 - 2014 (1) |
| Highly cited | No |