Transient Dysregulation of Dopamine Signaling in a Developing Drosophila Arousal Circuit Permanently Impairs Behavioral Responsiveness in Adults
Bibliographic Data
| ID | 15520643 |
|---|---|
| Authors | Lachlan A Ferguson (0000-0003-4048-4137, The University of Queensland), Lachlan Ferguson, Alice Petty (0000-0001-7058-4185, The University of Queensland), Chelsie Rohrscheib (0000-0003-1668-514X, The University of Queensland), Michael Troup (0000-0003-3017-7029, The University of Queensland), Leonie Kirszenblat (0000-0002-7755-8534, The University of Queensland), Darryl W Eyles (0000-0002-5023-7095, The University of Queensland), Bruno Van Swinderen (0000-0001-6552-7418, The University of Queensland, corresponding author) |
| Year | 2017 |
| Volume | 8 |
| Pages | 22-22 |
| Publication date | 2017-02-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2017.00022 |
| PMID | 28243212 |
| OpenAlex | W2587878891 |
| Language | EN |
| Citations received | 1 |
| References cited | 47 |
The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine signaling in the developing fruit fly Drosophila melanogaster and examined behavioral responsiveness in adult flies. We found that either a transient increase of dopamine neuron activity or a transient decrease of dopamine receptor expression during fly brain development permanently impairs behavioral responsiveness in adults. A screen for impaired responsiveness revealed sleep-promoting neurons in the central brain as likely postsynaptic dopamine targets modulating these behavioral effects. Transient dopamine receptor knockdown during development in a restricted set of ~20 sleep-promoting neurons recapitulated the dopamine ontogeny phenotype, by permanently reducing responsiveness in adult animals. This suggests that disorders involving impaired behavioral responsiveness might result from defective ontogeny of sleep/wake circuits
Biology · Dopamine · Dopamine receptor · Dopamine transporter · Dopaminergic · Drosophila melanogaster · Circadian rhythm and melatonin · Neurobiology and Insect Physiology Research · Neuroscience · Plant and animal studies · Psychology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,11 |
| Citation span | 2017 - 2017 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |