Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia
Bibliographic Data
| ID | 15520679 |
|---|---|
| Authors | Zuoli Sun (0000-0003-1062-2009, Beijing Anding Hospital), Lei Zhao (0000-0001-9914-0385, Capital Medical University), Qijing Bo (0000-0002-3275-7978, Beijing Anding Hospital), Zhen Mao (0000-0001-8920-0348, Beijing Anding Hospital), Yi He (0000-0002-5562-4190, Beijing Anding Hospital), 一彦 須賀 (0000-0002-6816-8198), Tao Jiang (0000-0001-5221-2951, Beijing Anding Hospital), Yuhong Li (0000-0003-0056-8862, Capital Medical University), Chuan-Yue Wang (0000-0001-6549-3713, Capital Medical University, corresponding author), Chuanyue Wang, Rena Li (0000-0001-9729-9472, Beijing Anding Hospital, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 711734-711734 |
| Publication date | 2021-08-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.711734 |
| PMID | 34408685 |
| OpenAlex | W3191340086 |
| Language | EN |
| Citations received | 1 |
| References cited | 108 |
Accumulating evidence from clinical, genetic, and epidemiologic studies suggest that schizophrenia might be a neuronal development disorder. While oxysterols are important factors in neurodevelopment, it is unknown whether oxysterols might be involved in development of schizophrenia. The present study investigated the relationship between tissue-specifically originated oxysterols and risk of schizophrenia. A total of 216 individuals were recruited in this study, including 76 schizophrenia patients, 39 clinical high-risk (CHR) subjects, and 101 healthy controls (HC). We investigated the circulating levels of brain-specific oxysterol 24(S)-hydroxycholesterol (24OHC) and peripheral oxysterol 27-hydroxycholesterol (27OHC) in all participants and analyzed the potential links between the oxysterols and specific clinical symptoms in schizophrenic patients and CHR. Our data showed an elevation of 24OHC in both schizophrenia patients and CHR than that in HC, while a lower level of 27OHC in the schizophrenia group only. The ratio of 24OHC to 27OHC was only increased in the schizophrenic group compared with CHR and HC. For the schizophrenic patients, the circulating 24OHC levels are significantly associated with disease duration, positively correlated with the positive and negative syndrome total scores, while the 27OHC levels were inversely correlated with the positive symptom scores. Together, our data demonstrated the disruption of tissue-specifically originated cholesterol metabolism in schizophrenia and CHR, suggesting the circulating 24OHC or 24OHC/27OHC ratio might not only be a potential indicator for risk for schizophrenia but also be biomarkers for functional abnormalities in neuropathology of schizophrenia
Biology · Biomarker · Cholesterol · Disease · Neuropathology · Oxysterol · Positive and Negative Syndrome Scale · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Cholesterol and Lipid Metabolism · Medicine · Psychology · Receptor Mechanisms and Signaling · Sphingolipid Metabolism and Signaling · Endocrinology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |