Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis
A Mendelian Randomization Study
Bibliographic Data
| ID | 15520732 |
|---|---|
| Authors | Anton Iftimovici (0000-0003-4927-2798, Inserm), Oussama Kébir (0000-0002-3233-094X, Inserm), Qin He (0000-0002-7697-4034, Inserm), Thérèse M Jay (0000-0002-2468-1141, Inserm), ICAAR Study Group (Montreal Neurological Institute and Hospital), Guy A Rouleau (0000-0001-8403-1418, Montreal Neurological Institute and Hospital), Marie-Odile Krebs, Marie‐Odile Krebs (0000-0002-4715-9890, Inserm), Boris Chaumette (0000-0002-1313-2788, Inserm, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 680-680 |
| Publication date | 2020-07-10 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.00680 |
| PMID | 32754072 |
| OpenAlex | W3041903418 |
| Language | EN |
| References cited | 38 |
For the same level of cortisol, NR3C1 expression increases psychotic risk, independently of sex, age, cannabis, and antipsychotic intake. In females, Mendelian randomization confirmed NR3C1 's effect on outcome to be unbiased by any environmental confounder
Antipsychotic · Biology · Cannabis · Confounding · Gene · Genotype · Mendelian randomization · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Clinical Psychology · Hormonal Regulation and Hypertension · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Genetics · Internal Medicine · Oncology
Mapping the Onset of Psychosis
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
The Psychosis High-Risk State
Second-generation PLINK
‘Mendelian randomization’
Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
| Citation velocity | historical |
|---|---|
| Highly cited | No |