Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats
Bibliographic Data
| ID | 15520751 |
|---|---|
| Authors | Simeng Gu (0000-0002-7018-8075, Nanjing University of Chinese Medicine, corresponding author), Liyuan Jing (0000-0003-4042-859X, Nanjing University of Chinese Medicine), Yang Li (0000-0002-2835-6661, Nanjing University of Chinese Medicine), Jason H Huang (0000-0002-4426-0168, Texas A&M University), Fushun Wang (0000-0002-6433-6940, Baylor Scott & White Health) |
| Year | 2018 |
| Volume | 9 |
| Pages | 253-253 |
| Publication date | 2018-06-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00253 |
| PMID | 29951006 |
| OpenAlex | W2804988746 |
| Language | EN |
| Citations received | 2 |
| References cited | 4 |
Objective: Previously, we showed that neuromodulators are important factors involved in depression, here we aim to further investigate the interactions between neuromodulators and sex hormone involved in menopause related depression in rats. Methods: Menopausal depression was made with bilateral ovariectomies in female SD rats followed by chronic mild unpredictable stress treatment for 21 days. Thirty six rats were randomly divided into four groups: sham surgery group, sham/stress group, surgery group, surgery/stress group. Then open-field locomotor scores and sucrose intake were employed to observe behavior changes. The levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) in the cerebral spinal fluid and serum adrenocorticotropic hormone (ACTH), cortisone were determined with High-performance liquid chromatography (HPLC). Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured with radioimmunoassay. Results: The open-field locomotor scores and sucrose intake were significantly decreased after the surgery and stress treatment ( p 2 level decreased significantly after the surgery ( p p p 2 . Conclusion: Ovary removal rats showed depression-like behaviors, with LH and FSH increase and monoamine decrease, and the levels of these monoamines in the stress treated groups changed only after the stressful treatment. The LH, FSH hormone increasing might be the reason for the lower monoamine release, which in turn might be the reason for depressed syndromes in the menopause. The cortisone and ACTH in the serum in the surgery/stress group were much higher than that in the sham surgery group
Hormone · Psychiatry · Biochemical effects in animals · Clinical Psychology · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2018 - 2021 (4) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |