Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression

A modulating role of gene-stressor interactions

Bibliographic Data

ID15520754
AuthorsYuko Hakamata (0000-0002-5717-8091, National Institute of Mental Health, corresponding author), Hiroaki Hori (0000-0002-4548-7110, National Center of Neurology and Psychiatry), Shinya Mizukami (Kitasato University), Shuhei Izawa (0000-0003-1399-1512, National Institute of Occupational Safety and Health), Fuyuko Yoshida (National Center of Neurology and Psychiatry), Yoshiya Moriguchi (0000-0001-9248-8864, National Center of Neurology and Psychiatry), Takashi Hanakawa (0000-0003-3267-8214, Kyoto University), Yusuke Inoue (0000-0003-4298-9737, Kitasato University), Hirokuni Tagaya (0000-0002-4041-3497, Kitasato University)
Year2023
Volume14
Pages1196235-1196235
Publication date2023-05-30
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2023.1196235
PMID37324818
OpenAlexW4380869966
LanguageEN
References cited98

Here we show that the blunted interleukin-6 diurnal rhythm predicts depressive symptoms, modulated by amygdala emotional hyporeactivity and gene-stressor interactions. These findings indicate a potential mechanism underlying vulnerability to depressive disorders, suggesting their early detection, prevention, and treatment through the understanding of immune system dysregulation

Amygdala · Anxiety · Depression (economics · Major depressive disorder · Psychiatry · Psychopathology · Stressor · Clinical Psychology · Medicine · Mental Health Research Topics · Neuroscience · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Internal Medicine

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