Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats

Bibliographic Data

ID15520980
AuthorsIlya S Zhukov (0000-0001-7945-5486, St Petersburg University, corresponding author), Yazen Alnefeesi (0000-0002-1952-0677, St Petersburg University), Natalia A Krotova (National Research University Higher School of Economics), Natalya A Krotova, Vsevolod V Nemets (0000-0002-1222-6926, St Petersburg University), Konstantin A Demin (0000-0003-1853-0475, St Petersburg University), Marina N Karpenko (0000-0002-1082-0059, Institute of Experimental Medicine), Evgeny A Budygin (0000-0002-5675-0279, Sirius University of Science and Technology), Evgeny Kanov (St Petersburg University), Evgeny V Kanov, Allan V Kalueff (0000-0002-7525-1950, St Petersburg University), Петр Д Шабанов (0000-0003-1464-1127, Institute of Experimental Medicine), Petr D Shabanov, Michael Bader (0000-0003-4780-4164, Max Delbrück Center), Natália Alenina (0000-0002-6071-5433, Max Delbrück Center), Raul R Gainetdinov (0000-0003-2951-6038, St Petersburg University)
Year2024
Volume15
Pages1484925-1484925
Publication date2024-12-19
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2024.1484925
PMID39748904
OpenAlexW4405600820
LanguageEN
References cited78

Results supported social rank advancement as the main incentive. These data also suggest that TAAR1 is a promising target for the development of new treatments for aggression; independent data also support this conclusion

5-HT receptor · Aggression · Agonist · Amino acid · Psychiatry · Receptor · Serotonergic · Serotonin · Tryptophan · Tryptophan hydroxylase · Chemistry · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology · Treatment of Major Depression · Tryptophan and brain disorders · Biochemistry · Endocrinology · Internal Medicine · Pharmacology

Tools

Open DOIOpen Access