Impact of negative symptoms on health-related quality of life in schizophrenia
Bibliographic Data
| ID | 15522126 |
|---|---|
| Authors | Yanhui Li (0000-0002-8195-3748, Institute of Mental Health, corresponding author), Gurpreet Rekhi (0000-0002-9014-5718, Institute of Mental Health), Mei San Ang (0000-0002-3172-3231, Institute of Mental Health), Jimmy Lee (0000-0002-8063-6855, Nanyang Technological University) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1252354-1252354 |
| Publication date | 2023-09-07 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1252354 |
| PMID | 37744001 |
| OpenAlex | W4386527818 |
| Language | EN |
| References cited | 51 |
Evidence regarding the association of Negative Symptoms (NS) dimensions with Health-related Quality of Life (HRQoL) is limited and no prior study has looked into contributions of NS domains on HRQoL. This study bridges the gap by examining the associations of NS, its two dimensions (Motivation and Pleasure, and Emotional Expressivity) and five domains (Anhedonia, Avolition, Asociality, Blunted affect and Alogia) with HRQoL in schizophrenia. 274 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptom Scale (BNSS). PANSS scores were mapped to EuroQol five-dimensional (EQ-5D-5L) utility scores using an algorithm previously validated in Singapore, and the resulting EQ-5D-5L scores were used as a measure of HRQoL. Multiple linear regression analyses of the two NS dimensions and five NS domains against EQ-5D-5L showed that a lower severity of NS, specifically that of the Motivation and Pleasure (MAP) dimension and asociality domain was associated with higher HRQoL. Our findings highlight the importance of targeting NS, particularly MAP and asociality, in improving HRQoL in schizophrenia
Affect (linguistics · Anhedonia · Pleasure · Positive and Negative Syndrome Scale · Psychiatry · Psychosis · Psychotherapist · Quality of life (healthcare · Schizophrenia (object-oriented programming · Clinical Psychology · Mental Health and Psychiatry · Mental Health Research Topics · Psychology · Schizophrenia research and treatment
A Critical Appraisal of the Quality of Quality-of-Life Measurements
Eq-Sd
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
The MOS 36-ltem Short-Form Health Survey (SF-36)
How Many Subjects Does It Take To Do A Regression Analysis
Quantitative and Qualitative Aspects of the Social Network in Schizophrenic Patients Living in the Community. Relationship To Sociodemographic Characteristics and Clinical Factors and Subjective Quality of Life
Determinants of Health-Related Quality of Life in Schizophrenia
Determinants of objective and subjective quality of life in first-time-admission schizophrenic patients in Poland
Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
Generic and Disease-Specific Measures in Assessing Health Status and Quality of Life
Age, Gender and Quality of Life
| Highly cited | No |
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