Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Bibliographic Data

ID15522256
AuthorsGuangcheng Cui (0000-0002-1607-4130, Qiqihar Medical University), Yangpan Ou (0009-0007-0691-8057, Central South University), Yunhui Chen (0000-0002-1684-2507, Qiqihar Medical University), Dan Lv (0009-0008-5758-8112, Qiqihar Medical University), Cuicui Jia (0009-0001-9023-8033, Qiqihar Medical University), Zhaoxi Zhong (0000-0001-9109-6172, Xinxiang Medical University), Ru Yang (0000-0002-3299-2345, Second Xiangya Hospital of Central South University), Yuhua Wang (0000-0003-4311-5425, Qiqihar Medical University), Xin Meng (0000-0003-3899-1471, Qiqihar Medical University), Hongsheng Cui (0000-0002-8900-8222, Qiqihar Medical University), Chengchong Li (Qiqihar Medical University), Zhenghai Sun (Qiqihar Medical University), Xiaoping Wang (0000-0002-7862-0491, Second Xiangya Hospital of Central South University), Wenbin Guo (0000-0002-1626-2465, Second Xiangya Hospital of Central South University, corresponding author), Ping Li (0000-0002-0813-0980, Qiqihar Medical University, corresponding author)
Year2020
Volume11
Pages98-98
Publication date2020-03-03
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.00098
PMID32194450
OpenAlexW3009204713
LanguageEN
Citations received2
References cited53

Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise global brain FC (GFC) analysis at rest. Compared with HCs, patients with OCD showed decreased GFC within the default mode network (DMN) (i.e., left posterior cingulate cortex/lingual gyrus) and sensorimotor network (i.e., left precentral gyrus/postcentral gyrus) and increased GFC within the executive control network (ECN) (i.e., left dorsal lateral prefrontal cortex and left inferior parietal lobule). Receiver operating characteristic curve analyses further indicated that the altered GFC values within the DMN, ECN, and sensorimotor network may be used as neuroimaging markers to differentiate patients with OCD from HCs. These findings indicated the aberrant FC patterns of the DMN, ECN, and sensorimotor network associated with the pathophysiology of OCD and provided new insights into the changes in brain organization function in OCD

Anterior cingulate cortex · Cognition · Cortex (anatomy · Default mode network · Drug · Drug-naïve · Functional magnetic resonance imaging · Inferior parietal lobule · Magnetic resonance imaging · Neuroimaging · Pathophysiology · Postcentral gyrus · Posterior cingulate · Precentral gyrus · Prefrontal cortex · Psychiatry · Supplementary motor area · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Functional Brain Connectivity Studies · Medicine · Neuroscience · Obsessive-Compulsive Spectrum Disorders · Psychology · Internal Medicine

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