Claudin-5 and inflammatory biomarkers in panic disorder

In subjects presenting with PD symptoms, increased parameters that may be associated with increased inflammation (such as CRP, CRP/albumin ratio, and neutrophil count), along with claudin-5 levels and the association between them, and the decrease in claudin-5 levels after a 6-week follow-up following a decrease in PD symptom severity, suggest that alterations in claudin-5 level in PD may be related to PD symptomatology. The high level of claudin-5 at the initial clinical presentation may be explained as a direct consequence of neuroinflammation in PD and/or as a compensatory change that occurs secondary to the neuroinflammation in PD. It can be assumed that as PD symptom severity decreases, neuroinflammation decreases, and claudin-5 production slows down

Biomarker · Immune system · Inflammation · Neuroinflammation · Panic · Panic disorder · Barrier Structure and Function Studies · Neuroinflammation and Neurodegeneration Mechanisms · Tryptophan and brain disorders