Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide
From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs
Bibliographic Data
| ID | 15522684 |
|---|---|
| Authors | Micaela Tirri (0000-0001-9337-9184, University of Ferrara), Sabrine Bilel (0000-0003-1515-980X, University of Ferrara), Raffaella Arfè (0000-0003-2614-2368, University of Ferrara), Giorgia Corli (0000-0002-2973-2446, University of Ferrara), Beatrice Marchetti (University of Ferrara), Tatiana Bernardi (0000-0001-5452-5775, University of Ferrara), Federica Boccuto (0000-0003-4786-3586, University of Ferrara), Giovanni Serpelloni (0000-0003-2616-5762, University of Verona), Francesco Botrè (0000-0001-5296-8126, University of Lausanne), Fabio De‐Giorgio (0000-0001-7433-0924, Università Cattolica del Sacro Cuore, corresponding author), Krystyna Gołembiowska (0000-0002-5018-1394, Polish Academy of Sciences), Matteo Marti (0000-0001-8751-2882, University of Ferrara, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 875722-875722 |
| Publication date | 2022-04-21 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.875722 |
| PMID | 35530025 |
| OpenAlex | W4224301560 |
| Language | EN |
| References cited | 75 |
In the last decade, the market for new psychoactive substances has been enriched by numerous psychedelic phenethylamines, which mimic the psychoactive effect of lysergic acid diethylamide (LSD). In particular, the -NBOMe series, which are more potent than their 2C compounds analogs, are considered worthy substitutes for LSD by users. The purpose of this study was to assess the effects of 25 H -NBOMe and its halogenated derivatives (25 I -NBOMe and 25 B -NBOMe) in comparison to their 2C compounds analogs and LSD on the sensorimotor (visual, acoustic, and overall tactile), reaction time, spontaneous (total distance traveled) and stimulated (drag, accelerod test) motor activity, grip strength test, and prepulse inhibition (PPI) responses in mice. Systemic administration of -NBOMe, 2C compounds analogs, and LSD (0.001-10 mg/kg) differently impaired the sensorimotor, reaction time, motor, and PPI responses in mice. In particular, halogenated (25I and 25B)-NBOMe derivatives appear to be more effective than the entire class of 2C compounds analogs in altering visual and acoustic responses, affecting reaction time, and motor and sensory gating in PPI test. In fact, the specific rank order of compounds potency for nearly all of the experiments showed that (25I and 25B)-NBOMe were more potent than 2C compounds analogs and LSD. -NBOMe and 2C compounds analogs impaired not only the reception of incoming sensory stimuli (visual and acoustic), but their correct brain processing (PPI) in an equal and sometimes stronger way than LSD. This sensory impairment directly affected the spontaneous motor response and reaction time of mice, with no change in performance in stimulated motor activity tests. These aspects should be carefully considered to better understand the potential danger that psychedelic phenethylamines, in particular -NBOMe, may pose to public health, with particular reference to decreased performance in driving and hazardous works that require special sensorimotor skills
Gating · Hallucinogen · Lysergic acid diethylamide · Prepulse inhibition · Schizophrenia (object-oriented programming · Sensory gating · Chemical synthesis and alkaloids · Chemistry · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychedelics and Drug Studies · Psychology · Biochemistry · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |