Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats
Bibliographic Data
| ID | 15522757 |
|---|---|
| Authors | Jia-Wei Zeng (0009-0002-6020-2686, Hubei University of Chinese Medicine), Zhen-Jie Han (Hubei University of Chinese Medicine), Xi He (0009-0006-7287-9351, Jingchu University of Technology), Xiu-Tang He, Xuejiao Liu (0009-0005-7045-6323, Hubei University of Chinese Medicine), Xue-jiao Liu, Hui-yue Wang (Hubei University of Chinese Medicine), Shusheng Yang (Wuhan Red Cross Hospital), Shu-Sheng Yang, Jing Bai (0000-0001-6957-190X, Hubei University of Chinese Medicine, corresponding author), Yanjun Duan (0000-0002-1351-7397, Hubei University of Chinese Medicine, corresponding author), Yan-Jun Duan, Lin Li (0000-0003-2896-7988, Hubei University of Chinese Medicine, corresponding author), Li Lin (0000-0002-7584-9186) |
| Year | 2025 |
| Volume | 16 |
| Pages | 1628634-1628634 |
| Publication date | 2025-10-17 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1628634 |
| PMID | 41179813 |
| OpenAlex | W4415302877 |
| Language | EN |
| References cited | 69 |
Sini San modulates the gut-brain axis by inhibiting the NLRP3 inflammasome, thereby alleviating CUMS-induced inflammation and gut microbiota dysbiosis in rats. This effect may further contribute to the improvement of depressive symptoms via regulation of the BDNF/TrkB/PI3K/AKT signaling pathway
Cell Signaling · Depression (economics · Dysbiosis · Gut flora · Gut–brain axis · Inflammation · Signal transduction · Adipokines, Inflammation, and Metabolic Diseases · Stress Responses and Cortisol · Tryptophan and brain disorders
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017
SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway
Traditional Chinese herbal formula, Fuzi-Lizhong pill, produces antidepressant-like effects in chronic restraint stress mice through systemic pharmacology
Integrated network pharmacology and metabolomics to dissect the combination mechanisms of Bupleurum chinense DC-Paeonia lactiflora Pall herb pair for treating depression
| Citation velocity | historical |
|---|---|
| Highly cited | No |