Combination of Alprazolam and Bailemian Capsule Improves the Sleep Quality in Patients With Post-Stroke Insomnia

Insomnia is often ignored in the diagnosis and treatment of patients of stroke. The present study aimed to evaluate the efficacy of alprazolam (ALP) combined with Bailemian capsule (BC, a traditional Chinese patent medicine) in the treatment of post-stroke insomnia (PSI). A total of 231 stroke patients involved in this retrospective study were treated with ALP, BC, or ALP + BC for 3 weeks. The quality of sleep was evaluated by the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG), while self-care ability was monitored by the modified Rankin Scale (mRS) before and after treatment. Compared with the baseline, the self-care ability of patients in each group was significantly improved after treatment ( P P P P P P < 0.05). Importantly, the effect of the combination of ALP and BC was greater than the use of ALP or BC alone, which was consistent with the result of PSQI. In conclusion, the sleep quality and self-care ability of patients with PSI were improved by ALP and BC, thereby supporting the potential advantages of ALP combined with BC in the treatment of patients with PSI

Alprazolam · Anesthesia · Anxiety · Apnea · Epworth Sleepiness Scale · Hypnotic · Insomnia · Pittsburgh Sleep Quality Index · Polysomnography · Primary Insomnia · Psychiatry · Sleep (system call · Sleep disorder · Sleep onset latency · Sleep quality · Stroke (engine · Medicine · Neurological Disease Mechanisms and Treatments · Sleep and related disorders · Sleep and Wakefulness Research · Internal Medicine

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