Cariprazine Use in Early Psychosis
Three Case Reports
Bibliographic Data
| ID | 15522840 |
|---|---|
| Authors | Ricardo Coentre (0000-0002-2939-9436, Centro Hospitalar Lisboa Norte, corresponding author), Rodrigo Saraiva (0000-0003-1344-3612, University of Lisbon), Carolina Sereijo (Centro Hospitalar Lisboa Norte), Pedro Levy (0000-0002-2316-138X, Centro Hospitalar Lisboa Norte) |
| Year | 2021 |
| Volume | 12 |
| Pages | 788281-788281 |
| Publication date | 2021-12-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.788281 |
| PMID | 34975583 |
| OpenAlex | W4200005925 |
| Language | EN |
| Citations received | 1 |
| References cited | 39 |
Objective: Cariprazine is a new atypical antipsychotic approved for the acute and maintenance treatment of schizophrenia (1, 2) and for the treatment of manic or mixed episodes associated with bipolar I disorder (1). Recently, cariprazine also got extended FDA-approval for the treatment of depressive episodes in adults with bipolar I disorder (3). The use of low doses of atypical antipsychotics is an essential component of early intervention in psychosis. For its particular performance and tolerability, cariprazine is becoming an important option for the treatment of first-episode psychosis. Method: Three patients experiencing first-episode psychosis (FEP) were successfully treated with cariprazine. Two patients were in their first months of the disease, and the third patient was in his third year after the FEP. Results: The three patients had a diagnosis of non-affective FEP, which includes schizophrenia, delusional disorder, and schizoaffective disorder. One of them was in their third year after the FEP with a predominance of negative symptoms at this stage of the disorder. All the patients were treated with cariprazine with a target dose of 3-4.5 mg/day. The three patients showed improvements in their psychosis, including a decrease in negative symptoms. No significant side effects were reported. Conclusion: Our three case reports indicate that cariprazine is an atypical antipsychotic beneficial in the treatment of early psychosis. Treatment with low doses of cariprazine could be effective and tolerable in this phase of the disorder. Future studies with longer follow-up of FEP patients are recommended to confirm these positive results of cariprazine in the early phases of psychosis
Adverse effect · Akathisia · Antipsychotic · Atypical antipsychotic · Bipolar disorder · Bipolar I disorder · Delusional disorder · Mania · Mood · Paliperidone · Psychiatry · Psychosis · Schizoaffective disorder · Schizophrenia (object-oriented programming · Schizophreniform disorder · Tolerability · Bipolar Disorder and Treatment · Medicine · Neurotransmitter Receptor Influence on Behavior · Psychology · Schizophrenia research and treatment · Internal Medicine
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |