Violent Behavior Is Associated With Emotion Salience Network Dysconnectivity in Schizophrenia
Bibliographic Data
| ID | 15522848 |
|---|---|
| Authors | Andràs Tikàsz (0000-0002-0085-9830, Université de Montréal), Stéphane Potvin (0000-0003-1624-378X, Université de Montréal), Jules R Dugré (0000-0003-4946-0350, Institut Universitaire en Santé Mentale de Québec), Cherine Fahim (Centre Hospitalier Universitaire Sainte-Justine), Vesséla Zaharieva (Montreal Neurological Institute and Hospital), Olivier Lipp (Université de Montréal), Adrianna Mendrek (0000-0001-8056-5228, Institut Universitaire en Santé Mentale de Québec), Alexandre Dumais (0000-0002-4480-0064, Institut Universitaire en Santé Mentale de Québec, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 143-143 |
| Publication date | 2020-02-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.00143 |
| PMID | 32180744 |
| OpenAlex | W3007007166 |
| Language | EN |
| Citations received | 1 |
| References cited | 61 |
Background: Despite individuals with schizophrenia being at an elevated risk of violence compared to the general population, limited efforts have been invested in investigating the neurobiological etiology explaining the increase. Among the few studies examining functional disruptions pertaining to violent schizophrenia patients using fMRI, only one study has considered functional connectivity. The current state of knowledge does not allow to infer deficits in functional connectivity specific to distinct cognitive/emotional states that have been associated with the emergence of violence in schizophrenia, such as negative emotion processing. This study sought to identify disrupted connectivity among men with schizophrenia and a history of violence (SCZ+V), compared to men with schizophrenia without a history of violence (SCZ-V) and healthy controls, during negative emotion processing using fMRI. Methods: Twenty SCZ+V, 19 SCZ-V, and 21 healthy men were scanned while viewing negative images. Results: Negative images elicited an increased connectivity between the dorsal anterior cingulate cortex (dACC) and the bilateral rostral prefrontal cortex (rPFC), as well as a decreased functional connectivity between the frontal regions (bilateral rPFC and dACC) and the putamen and hippocampus in SCZ+V men as compared to SCZ-V men and healthy controls. Concurrently, the centrality of the dACC within the network was reduced in SCV+V subjects. Conclusions: These results suggest an inefficient integration of the information by the dACC between frontal and limbic regions in SCZ+V men during negative emotion processing and highlight the importance of the ACC in the neurobiological bases of violent behavior in schizophrenia
Anterior cingulate cortex · Cognition · Functional magnetic resonance imaging · Population · Prefrontal cortex · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Functional Brain Connectivity Studies · Medicine · Mental Health Research Topics · Neuroscience · Psychology · Schizophrenia research and treatment
Rethinking Risk Assessment
Conn
Conflict monitoring and anterior cingulate cortex
Complex network measures of brain connectivity
Dysfunction in the Neural Circuitry of Emotion Regulation--A Possible Prelude to Violence
Emotional processing in anterior cingulate and medial prefrontal cortex
Meeting of minds
Schizophrenia and Violence
Emotion regulation and aggression
The Structured Clinical Interview for DSM-III-R (SCID)
Cognitive and emotional influences in anterior cingulate cortex
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |