Childhood Maltreatment Was Correlated With the Decreased Cortical Function in Depressed Patients Under Social Stress in a Working Memory Task
A Pilot Study
Bibliographic Data
| ID | 15522907 |
|---|---|
| Authors | Mengying Ma (Peking University), Xiao Zhang (0000-0002-0342-3282, Peking University Sixth Hospital, corresponding author), Yuyanan Zhang (0000-0002-0474-1135, Peking University), Yi Su (0000-0002-0203-615X, Peking University), Hao Yan (0000-0002-5268-7153, Peking University), Hao Yang Tan (0000-0003-3561-2093, Johns Hopkins University), Dai Zhang (0000-0002-9162-7401, Peking University Sixth Hospital), Weihua Yue (0000-0002-1201-8465, Peking University Sixth Hospital, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 671574-671574 |
| Publication date | 2021-07-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.671574 |
| PMID | 34305677 |
| OpenAlex | W3181028172 |
| Language | EN |
| References cited | 6 |
Background: Major depressive disorder (MDD) is a common psychiatric disorder associated with working memory (WM) impairment. Neuroimaging studies showed divergent results of the WM process in MDD patients. Stress could affect the occurrence and development of depression, in which childhood maltreatment played an important role. Methods: Thirty-seven MDD patients and 54 healthy control subjects were enrolled and completed a WM functional magnetic resonance imaging task with maintenance and manipulation conditions under stress and non-stress settings. We collected demographical and clinical data, using 17-item Hamilton Depression Scale (HAMD-17) and Childhood Trauma Questionnaire (CTQ) in MDD patients. In the WM task, we analyzed the main diagnosis effect and explored the correlation of impaired brain regions in MDD patients with CTQ and HAMD-17. Results: No group differences were found in the accuracy rate and reaction time between the two groups. MDD patients had lower brain activation in following regions ( P FWE P Bonferroni Conclusions: In our pilot study, MDD patients had reduced brain activation, affecting emotional stimuli processing function, executive function, and cognitive control function. Childhood maltreatment might affect brain function in MDD. This work might provide some information for future studies on MDD
Anterior cingulate cortex · Anxiety · Cognition · CTQ tree · Depression (economics · Functional magnetic resonance imaging · Hamd · Injury prevention · Major depressive disorder · Poison control · Prefrontal cortex · Psychiatry · Working memory · Child Abuse and Trauma · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Neuroscience · Psychology
| Citation velocity | historical |
|---|---|
| Highly cited | No |