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Measurement of Striatal Dopamine Release Induced by Neuropsychological Stimulation in Positron Emission Tomography With Dual Injections of [11C]Raclopride

Bibliographic Data

ID15522928
AuthorsYoko Ikoma (National Institutes for Quantum Science and Technology, corresponding author), Yasuyuki Kimura (0000-0002-7927-9483, National Institutes for Quantum Science and Technology), Makiko Yamada (0000-0002-2897-3045, National Institutes for Quantum Science and Technology), Takayuki Obata (0000-0001-7678-5033, National Institutes for Quantum Science and Technology), Tetsuya Suhara (0000-0003-2916-225X, National Institutes for Quantum Science and Technology), Hiroshi Ito (0000-0001-7611-9292, National Institutes for Quantum Science and Technology)
Year2022
Volume13
Pages811136-811136
Publication date2022-07-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.811136
PMID35903633
OpenAlexW4285022877
LanguageEN
References cited32

Our results indicate that the cognitive task-induced changes in dopamine-related systems may be complex and difficult to measure accurately using PET scans. However, the proposed dual-bolus injection approach provided reliable BP estimates with high reproducibility, suggesting that it has the potential to improve the accuracy of PET scans for measuring changes in dopamine concentrations

Cognition · Dopamine · Dopamine receptor D2 · Neuropsychology · Positron emission tomography · Raclopride · Stimulation · Advanced MRI Techniques and Applications · Functional Brain Connectivity Studies · Medical Imaging Techniques and Applications · Medicine · Neuroscience · Psychology

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