Improvement of working memory in older adults with mild cognitive impairment after repetitive transcranial magnetic stimulation – a randomized controlled pilot study
Bibliographic Data
| ID | 15522960 |
|---|---|
| Authors | Adrianna Senczyszyn (0000-0002-4986-0074, Wroclaw Medical University, corresponding author), Dorota Szczęśniak (0000-0002-8899-8842, Wroclaw Medical University), Tomasz Wieczorek (0000-0003-1014-5388, Wroclaw Medical University), Julian Maciaszek (0000-0002-4084-8220, Wroclaw Medical University), Monika Małecka (0000-0002-8473-6159, Wroclaw Medical University), Bogna Bogudzińska (Wroclaw Medical University), Anna Zimny (0000-0001-6214-0322, AGH University of Krakow), Karolina Fila-Witecka (0000-0002-8678-2554, Wroclaw Medical University), Karolina Fila-Pawłowska, Joanna Rymaszewska (0000-0001-8985-3592, Wrocław University of Science and Technology) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1196478-1196478 |
| Publication date | 2023-11-30 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1196478 |
| PMID | 38111617 |
| OpenAlex | W4389203903 |
| Language | EN |
| References cited | 44 |
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that could improve cognitive function. It is being developed as a non-pharmacological intervention to alleviate symptoms of cognitive deterioration. We assessed the efficacy of rTMS in improving cognitive functioning among people with Mild Cognitive Impairment (MCI) in a partially-blinded, sham-controlled randomized trial. Out of 91 subjects screened, 31 participants with MCI (mean age 70.73; SD = 4.47), were randomly assigned to one of three groups: (A) Active rTMS; (B) Active rTMS with Computerized Cognitive Training RehaCom; and (C) Sham control. The study evaluated cognitive function using the DemTect, FAS, and CANTAB tests before and after the stimulation. The following treatment protocol was applied: 2000 pulses at 10 Hz, 5-s train duration, and 25-s intervals at 110% of resting MT delivered over the left Dorsolateral Prefrontal Cortex (DLPFC) five times a week for 2 weeks. After 10 sessions of high-frequency rTMS, there was an improvement in overall cognitive function and memory, assessed by the DemTect evaluation, with no serious adverse effects. Analysis of differences in time (after 10 sessions) between studied groups showed statistically significant improvement in DemTect total score (time by group interaction p = 0.026) in favor of rTMS+RehaCom. The linear regression of CANTAB Paired Associates Learning revealed significant differences in favor of rTMS+RehaCom in three subtests. Our study shows that 10 sessions of rTMS over the left DLPFC (alone as well as combined with Computerized Cognitive Training) can have a positive impact on cognitive function in people with MCI. Further research should investigate the underlying mechanism and determine the optimal parameters for rTMS, which will be important for its efficacy in clinical settings
Audiology · Cognition · Cognitive Training · Dorsolateral prefrontal cortex · Effects of sleep deprivation on cognitive performance · Physical medicine and rehabilitation · Prefrontal cortex · Randomized controlled trial · Stimulation · Transcranial magnetic stimulation · Working memory · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Spatial Neglect and Hemispheric Dysfunction · Transcranial Magnetic Stimulation Studies · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |