Analysis of Psychological and Gut Microbiome Characteristics in Patients With Non-erosive Reflux Disease
Bibliographic Data
| ID | 15523197 |
|---|---|
| Authors | Fan Yang (0000-0003-2978-7102, Peking University Shenzhen Hospital), Xin‐hui Xie (0000-0002-3603-3854, Second Hospital of Anhui Medical University), Xin-Hui Xie, Xi Li (0000-0003-3519-4805, Peking University Shenzhen Hospital), Hui-na Liao (Peking University Shenzhen Hospital), Bing Zou (0000-0002-3514-5176, Peking University Shenzhen Hospital, corresponding author) |
| Year | 2022 |
| Volume | 12 |
| Pages | 741049-741049 |
| Publication date | 2022-01-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.741049 |
| PMID | 35095588 |
| OpenAlex | W4206072235 |
| Language | EN |
| References cited | 46 |
Objective: To assess the correlation between the incidence of non-erosive reflux disease (NERD) and psychological factors, especially somatoform disorders. To investigate the characteristics of gut microbiome in NERD patients. Methods: We enrolled 24 NERD patients and 24 healthy controls. All patients were evaluated via GerdQ, SOMS-7, SAS, HAMA, and HAMD. Fecal samples were collected and 16S rRNA sequencing was performed to evaluate the gut microbiome composition. Results: The main symptoms of the NERD patients were regurgitation (87.5%), belching (66.7%), pharyngeal discomfort (50%), and heartburn (37.5%). The average score of GerdQ was 13.42 ± 3.41. In 15 patients (62.5%), the total score of the last two items was P P = 0.026), male and female patients ( P = 0.009). The beta-diversity was also significantly different between male and female patients ( P = 0.009). There were several bacteria with significant differences between HC and NERD group, and NERD patients with or without somatoform disorders, such as Firmicutes, TM7 were enriched in the NERD group compared with the healthy control group, while Bacteroidetes were enriched in the healthy controls. Conclusions: NERD symptoms overlap with somatoform disorders. NERD symptoms have an impact on the daily life quality of patients. Some of them are accompanied by anxiety and depression of different degrees, and the two are significantly correlated. The diversity of gut microbiome in patients with NERD is significantly higher than healthy controls, which has its characteristics. The predominant bacteria in gut microbiome of patients with NERD are similar to the healthy population, with Firmicutes and Bacteroidetes as the main ones. The composition of gut microbiome in NERD patients with or without somatoform disorder is significantly different, which may be related to the interaction of microbiome-brain-gut axis
Anxiety · Bioinformatics · Biology · Depression (economics · Disease · GERD · Hamd · Heartburn · Incidence (geometry · Microbiome · Nerd · Psychiatry · Reflux · Significant difference · Dysphagia Assessment and Management · Gastroesophageal reflux and treatments · Gut microbiota and health · Medicine · Gastroenterology · Internal Medicine
Metagenomic biomarker discovery and explanation
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
A Rating Instrument For Anxiety Disorders
A Rating Scale for Depression
Study on the Therapeutic Effects of Drug and Cognitive-Behavioral Therapy on Non-Erosive Reflux Disease Patients With Emotional Disorders
The Assessment of Anxiety States by Rating
| Highly cited | No |
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