Changes of adrenocorticotropic hormone rhythm and cortisol circadian rhythm in patients with depression complicated with anxiety and their effects on the psychological state of patients
Bibliographic Data
| ID | 15523532 |
|---|---|
| Authors | Zheng Xie (0000-0003-2492-0592, Zhengzhou University), Yajie Deng (0000-0002-5920-621X, Henan Provincial People's Hospital), Chunyu Xie (Henan Provincial Center for Disease Control and Prevention, corresponding author), Yuanlong Yao (Henan University) |
| Year | 2023 |
| Volume | 13 |
| Pages | 1030811-1030811 |
| Publication date | 2023-01-18 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.1030811 |
| PMID | 36741558 |
| OpenAlex | W4317104168 |
| Language | EN |
| Citations received | 1 |
| References cited | 33 |
Objective : This work was to explore the rhythm of adrenocorticotropic hormone (ACTH) and cortisol in patients with depression and anxiety and their effects on mental state. In this work, with depression complicated with anxiety patients as the A-MDD group ( n = 21), and depression without anxiety symptoms as the NA-MDD group ( n = 21). Firstly, data features were extracted according to the electroencephalo-graph (EEG) data of different patients, and a DR model was constructed for diagnosis. The Hamilton Depression Scale 24 (HAMD-24) was employed to evaluate the severity, and the ACTH and cortisol levels were detected and compared for patients in the A-MDD group and NA-MDD group. In addition, the psychological status of the patients was assessed using the Toronto Alexithymia Scale (TAS). As a result, the AI-based DR model showed a high recognition accuracy for depression. The HAMD-24 score in the A-MDD group (31.81 ± 5.39 points) was statistically higher than the score in the NA-MDD group (25.25 ± 5.02 points) ( P P > 0.05). The incidence of cortisol rhythm disorder (CRD) in the A-MDD group was much higher ( P P < 0.01). In conclusion, the AI-based DR Model achieves a more accurate identification of depression; depression with or without anxiety has different effects on the mental state of patients. CRD may be one of the biological markers of depression combined with anxiety
Adrenocorticotropic hormone · Anxiety · Circadian rhythm · Cognition · Depression (economics · Hamd · Hormone · Major depressive disorder · Psychiatry · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Mental Health Research Topics · Psychology · Psychosomatic Disorders and Their Treatments · Endocrinology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |