The Sensory Abnormality Mediated Partially the Efficacy of Repetitive Transcranial Magnetic Stimulation on Treating Comorbid Sleep Disorder in Autism Spectrum Disorder Children

Bibliographic Data

ID15523690
AuthorsLei Gao (0000-0002-8961-1734, Tianjin Medical University), Chen Wang (0000-0003-3042-291X, Tianjin Medical University), Xiao-rong Song (Tianjin Medical University), Li Tian (0000-0003-2141-781X, Tianjin Anding Hospital), Zhiyi Qu (0000-0002-0232-563X, Tianjin Medical University), Zhi-yi Qu, Yu Han (0000-0002-4427-3962, Tianjin Medical University), Xin Zhang (0000-0003-0184-5868, Tianjin Medical University, corresponding author)
Year2022
Volume12
Pages820598-820598
Publication date2022-01-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.820598
PMID35140641
OpenAlexW4211179365
LanguageEN
Citations received4
References cited51

Sleep disorder emerges as a common comorbidity in children with autism spectrum disorder (ASD), and the interaction between the core symptoms of ASD and its sleep disorder remains unclear. Repetitive transcranial magnetic stimulation (rTMS) was used on the bilateral dorsolateral prefrontal cortex (DLPFC) to investigate the efficacy of rTMS on the core symptoms of ASD and comorbid sleep problems as well as the mediation role of the ASD symptoms between rTMS intervention and sleep improvement. A total of 41 Chinese children with ASD and who met the criteria in the fifth edition of the American Diagnostic and Statistical Manual of Mental Disorders were recruited, and 39 of them (mean age: 9.0 ± 4.4 years old; the male-female ratio was 3.9: 1) completed the study with the stimulating protocol of high frequency on the left DLPFC and low frequency on the right DLPFC. They were all assessed three times (before, at 4 weeks after, and at 8 weeks after the stimulation) by the Children's Sleep Habits Questionnaire (CSHQ), Strengths and Difficulties Questionnaire (SDQ), Childhood Autism Rating Scale, Repetitive Behavior Questionnaire-2, and Short Sensory Profile (SSP). The repeated-measures ANOVA showed that the main effect of "intervention time" of CSHQ ( F = 25.103, P F = 6.345, P = 0.003), and SDQ ( F = 9.975, P < 0.001) was statistically significant. By Bayesian mediation analysis, we only found that the total score of SSP mediated the treating efficacy of rTMS on CSHQ (αβ = 5.11 ± 1.51, 95% CI: 2.50-8.41). The percentage of mediation effect in total effect was 37.94%. Our results indicated the treating efficacy of rTMS modulation on bilateral DLPFC for both autistic symptoms and sleep disturbances. The sensory abnormality of ASD mediated the improvement of rTMS on sleep problems of ASD

Audiology · Autism · Autism spectrum disorder · Psychiatry · Stimulation · Transcranial magnetic stimulation · Children's Physical and Motor Development · Clinical Psychology · Medicine · Neuroscience · Psychology · Sleep and Wakefulness Research · Transcranial Magnetic Stimulation Studies

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