A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder
Datos Bibliográficos
| ID | 15523902 |
|---|---|
| Autores | Thomas L Athey (0000-0002-8987-3486, Johns Hopkins University), Can Ceritoglu (0000-0001-6081-2551, Johns Hopkins University), Daniel J Tward (0000-0002-4607-6807, Johns Hopkins University), Kwame S Kutten (0000-0001-6735-1460, Johns Hopkins University), J Raymond DePaulo (0000-0001-9221-9226, Johns Hopkins University), Kara Glazer (Boston University), Fernando S Goes (0000-0001-6262-8264, Johns Hopkins University), John R Kelsoe (0000-0002-3013-2333, VA San Diego Healthcare System), Francis M Mondimore (0000-0003-1491-9563, Johns Hopkins University), Francis Mondimore, Caroline M Nievergelt (0000-0001-5766-8923, University of California San Diego), Kelly Rootes-Murdy (0000-0003-2704-2035, Georgia State University), Peter P Zandi (0000-0001-8423-2623, Johns Hopkins University), J Tilak Ratnanather (0000-0002-8631-489X, Johns Hopkins University), Pamela B Mahon (0000-0002-3947-441X, Harvard University, autor de correspondencia) |
| Año | 2021 |
| Volumen | 12 |
| Páginas | 614010-614010 |
| Fecha de publicación | 2021-02-16 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.614010 |
| PMID | 33664682 |
| OpenAlex | W3129298279 |
| Idioma | EN |
| Referencias citadas | 72 |
Research to discover clinically useful predictors of lithium response in patients with bipolar disorder has largely found them to be elusive. We demonstrate here that detailed neuroimaging may have the potential to fill this important gap in mood disorder therapeutics. Lithium treatment and bipolar disorder have both been shown to affect anatomy of the hippocampi and amygdalae but there is no consensus on the nature of their effects. We aimed to investigate structural surface anatomy changes in amygdala and hippocampus correlated with treatment response in bipolar disorder. Patients with bipolar disorder ( N = 14) underwent lithium treatment, were classified by response status at acute and long-term time points, and scanned with 7 Tesla structural MRI. Large Deformation Diffeomorphic Metric Mapping was applied to detect local differences in hippocampal and amygdalar anatomy between lithium responders and non-responders. Anatomy was also compared to 21 healthy comparison participants. A patch of the ventral surface of the left hippocampus was found to be significantly atrophied in non-responders as compared to responders at the acute time point and was associated at a trend-level with long-term response status. We did not detect an association between response status and surface anatomy of the right hippocampus or amygdala. To the best of our knowledge, this is the first shape analysis of hippocampus and amygdala in bipolar disorder using 7 Tesla MRI. These results can inform future work investigating possible neuroimaging predictors of lithium response in bipolar disorder
Amygdala · Anxiety · Bipolar disorder · Bipolar I disorder · Hippocampal formation · Hippocampus · Lithium (medication · Mania · Mood · Mood disorders · Neuroimaging · Psychiatry · Treatment of bipolar disorder · Advanced Neuroimaging Techniques and Applications · Bipolar Disorder and Treatment · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |