Intranasal esketamine as therapeutic option
A case report of an adolescent with treatment resistant depression
Bibliographic Data
| ID | 15524037 |
|---|---|
| Authors | Katrin Skala (Medical University of Vienna, corresponding author), Kamer Doganay (0000-0001-6517-5360, Medical University of Vienna), Harald Eder (Medical University of Vienna), Dunja Mairhofer (Medical University of Vienna), Katrin Neubacher (0000-0002-8958-7973, Medical University of Vienna), Paul L Plener (0000-0003-4333-1494, Universität Ulm) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1118737-1118737 |
| Publication date | 2023-06-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1118737 |
| PMID | 37333918 |
| OpenAlex | W4379233330 |
| Language | EN |
| References cited | 20 |
Depression is among the most common mental health disorders worldwide and treatment resistant depression (TRD) represents a major challenge for both patients and clinicians. In recent years ketamine has received attention as an antidepressant agent, demonstrating promising results in TRD in adults. To date, few attempts have been made in treating adolescent TRD with ketamine and none have used intranasal application. This paper discusses a case of a 17-year-old female adolescent suffering from TRD who underwent treatment with intranasal esketamine application (Spravato 28 mg). As symptoms showed clinically insignificant improvement despite modest gains in objective assessments (GAF, CGI, MADRS), treatment was prematurely discontinued. However, the treatment was tolerable and side effects were scarce and mild. Although this case report does not demonstrate clinical effectiveness, ketamine may nonetheless be a promising substance in treating TRD in other adolescents. Questions regarding the safety of ketamine use in the rapidly developing brains of adolescents still remain unanswered. To further explore the potential benefits of this treatment method a short term RCTs for adolescents with TRD is recommended
Antidepressant · Anxiety · Depression (economics · Ketamine · Mental health · Nasal administration · Psychiatry · Treatment-resistant depression · Medicine · Stress Responses and Cortisol · Treatment of Major Depression · Tryptophan and brain disorders · Pharmacology
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Annual Research Review
Neural and Behavioral Correlates of Clinical Improvement to Ketamine in Adolescents With Treatment Resistant Depression
| Citation velocity | historical |
|---|---|
| Highly cited | No |