Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
Bibliographic Data
| ID | 15524477 |
|---|---|
| Authors | Kai Wang (0000-0002-3784-1378), Ke Li (0009-0005-1439-1844, Zhengzhou University), Xiaoyu Niu (0000-0003-3152-8337, First Affiliated Hospital of Zhengzhou University) |
| Year | 2021 |
| Volume | 12 |
| Pages | 736755-736755 |
| Publication date | 2021-12-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.736755 |
| PMID | 34925086 |
| OpenAlex | W3215017043 |
| Language | EN |
| Citations received | 1 |
| References cited | 59 |
Purpose: This study aimed to explore alterations in functional connectivity (FC) within and between default mode network (DMN), central executive network, and salience network in autism spectrum disorder (ASD) with co-occurring attention deficit hyperactivity disorder (ADHD). Method: A total of 135 individuals' date of the Autism Brain Imaging Data Exchange II was used to compare the ASD+ADHD group with the ASD group in relation to the abnormal within-network and between-network connectivity of the ASD group relative to the TD group; consequently, the correlation analysis between abnormal FC and behavior was performed. Results: The ASD+ADHD group exhibited decreased within-network connectivity in the precuneus of the ventral DMN compared with the ASD group. Among the three groups, the ASD+ADHD group showed lower connectivity, whereas the ASD group had higher connectivity than the TD group, although the effect of the separate post hoc test was not significant. Meanwhile, the ASD+ADHD group showed increased between-network connectivity between the ventral DMN and dorsal DMN and between the ventral DMN and left executive control network, compared with the ASD and TD groups. Conclusion: Dysfunction of DMN in the "triple-network model" is the core evidence for ASD with co-occurring ADHD
Attention deficit · Autism · Autism spectrum disorder · Functional connectivity · Neurodevelopmental disorder · Psychiatry · Attention Deficit Hyperactivity Disorder · Functional Brain Connectivity Studies · Medicine · Mental Health Research Topics · Neuroscience · Psychology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |