Editome profiling and cross-cohort validation reveal A-to-I RNA editing dysregulation in the hippocampus and prefrontal cortex of sepsis patients
Bibliographic Data
| ID | 15524568 |
|---|---|
| Authors | Jie Shen (0000-0003-4131-1211, Jiangnan University, corresponding author), Jiaqi Pan (0000-0002-6001-8718, Jiangnan University), Jia-Qi Pan (Jiangnan University), Tian-yue Yu (Jiangnan University), Le-Wen Liu (Jiangnan University), Yunuo Li (Jiangnan University), Yu-Nuo Li (Jiangnan University), Yun-Yun Jin (Jiangnan University), Minmin Zhu (0000-0002-1899-802X, Jiangnan University) |
| Year | 2026 |
| Volume | 16 |
| Pages | 1742710-1742710 |
| Publication date | 2026-03-03 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1742710 |
| PMID | 41852687 |
| OpenAlex | W7133313420 |
| Language | EN |
| References cited | 44 |
Our results thus provide new insight into the importance of the clinical epitranscriptomic landscape in different brain regions during sepsis and warrant further investigation into therapeutic strategies to mitigate cognitive impairment in sepsis
ADAR · Gene knockdown · Hippocampal formation · Hippocampus · Prefrontal cortex · RNA · RNA editing · Sepsis · Infectious Encephalopathies and Encephalitis · Lysosomal Storage Disorders Research · RNA regulation and disease
| Highly cited | No |
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