The Effects of Transcranial Direct Current Stimulation on the Cognitive and Behavioral Changes After Electrode Implantation Surgery in Rats
Bibliographic Data
| ID | 15524682 |
|---|---|
| Authors | Jooyoung Oh (0000-0001-6721-399X, Yonsei University Health System), Jinsil Ham (0000-0002-6283-1315, Gwangju Institute of Science and Technology), Dongrae Cho (0000-0002-3741-3410, Gwangju Institute of Science and Technology), Jin Young Park (0000-0002-5351-9549, Yonsei University Health System), Jae‐Jin Kim (0000-0001-8990-2139), Jae-Jin Kim (0000-0002-1395-4562, Yonsei University Health System), Boreom Lee (0000-0002-7233-5833, Gwangju Institute of Science and Technology, corresponding author) |
| Year | 2019 |
| Volume | 10 |
| Pages | 291-291 |
| Publication date | 2019-05-07 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00291 |
| PMID | 31156472 |
| OpenAlex | W2944521324 |
| Language | EN |
| References cited | 63 |
Postoperative delirium can lead to increased morbidity and mortality, and may even be a potentially life-threatening clinical syndrome. However, the neural mechanism underlying this condition has not been fully understood and there is little knowledge regarding potential preventive strategies. To date, investigation of transcranial direct current stimulation (tDCS) for the relief of symptoms caused by neuropsychiatric disorders and the enhancement of cognitive performance has led to promising results. In this study, we demonstrated that tDCS has a possible effect on the fast recovery from delirium in rats after microelectrode implant surgery, as demonstrated by postoperative behavior and neurophysiology compared with sham stimulation. This is the first study to describe the possible effects of tDCS for the fast recovery from delirium based on the study of both electroencephalography and behavioral changes. Postoperative rats showed decreased attention, which is the core symptom of delirium. However, anodal tDCS over the right frontal area immediately after surgery exhibited positive effects on acute attentional deficit. It was found that relative power of theta was lower in the tDCS group than in the sham group after surgery, suggesting that the decrease might be the underlying reason for the positive effects of tDCS. Connectivity analysis revealed that tDCS could modulate effective connectivity and synchronization of brain activity among different brain areas, including the frontal cortex, parietal cortex, and thalamus. It was concluded that anodal tDCS on the right frontal regions may have the potential to help patients recover quickly from delirium
Anesthesia · Brain stimulation · Cognition · Cortex (anatomy · Delirium · Electroencephalography · Psychiatry · Stimulation · Thalamus · Transcranial Direct Current Stimulation · Functional Brain Connectivity Studies · Medicine · Neural dynamics and brain function · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies
| Highly cited | No |
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