High Bodyweight Variability Increases Depression Risk in Patients With Type 2 Diabetes Mellitus

A Nationwide Cohort Study in Korea

Bibliographic Data

ID15524940
AuthorsJi Hyun An (0000-0002-1628-9617, Sungkyunkwan University), Kyungdo Han (0000-0002-6096-1263, Soongsil University), Kyung-Do Han, Jin‐Hyung Jung (0000-0002-8920-8777, Catholic University of Korea), Jin-Hyung Jung, Juhwan Yoo (0000-0001-5112-0369, Catholic University of Korea), Maurizio Fava (0000-0002-4635-0458, Harvard University), David Mischoulon (0000-0001-7233-5860, Harvard University), Sumin Jung (0000-0002-3896-1929, Samsung Medical Center), Su-Min Jung, Dong Wook Shin (0000-0001-8128-8920, Samsung Medical Center), Kyu Yeon Hur (0000-0002-3065-7252, Sungkyunkwan University), Hong Jin Jeon (0000-0002-6126-542X, Sungkyunkwan University, corresponding author)
Year2021
Volume12
Pages765129-765129
Publication date2021-12-10
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.765129
PMID34955919
OpenAlexW4200619999
LanguageEN
Citations received3
References cited45

Objectives: Although obesity is associated with increased risk for depression in patients with type 2 diabetes mellitus (DM), the relationship between body weight variability (BWV) and depression remains poorly studied. This study was to investigate the incidence of depression in patients with type 2 DM according to their BWV. Methods: Intraindividual variation in body weight were measured in the nationwide, population-based retrospective cohort of 540,293 patients with type 2 DM from the Korean national health insurance system between 2009 and 2010. The diagnoses of new-onset depression occurring until the end of 2017 were ascertained. Risk of new-onset depression was examined using multivariate-adjusted Cox proportional hazards regression analysis by BWV quartile. Results: 93,149 (17.2%) patients developed new-onset depression for the follow up. BWV was significantly associated with an increased risk of depression after adjusting for confounding factors. The highest BWV quartile group had a hazard ratio (HR) of 1.17 (95% CI 1.15-1.19) compared to the lowest BWV quartile group as a reference. Obese patients in the highest BWV quartile group showed 12% increased risk of depression (HR 1.12, 95% CI 1.09-1.15) while non-obese patients in the highest BWV quartile group showed 20% increased risk of depression (HR: 1.20, 95% CI: 1.17-1.23) compared to their respective lowest BWV quartile groups. Conclusion: A higher BWV was significantly associated with an increased risk of depression in patients with type 2 DM. Thus, BWV may serve as an indicator for early detection of depression in type 2 DM patients

Cohort · Cohort study · Depression (economics · Diabetes mellitus · Psychiatry · Type 2 diabetes · Type 2 Diabetes Mellitus · Diabetes Management and Education · Diet and metabolism studies · Medicine · Obesity and Health Practices · Endocrinology · Gerontology · Internal Medicine

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