Early-Onset Depression in Stroke Patients
Effects on Unfavorable Outcome 5 Years Post-stroke
Bibliographic Data
| ID | 15525101 |
|---|---|
| Authors | Ya‐Ying Zeng (Wenzhou Medical University), Meng‐Xuan Wu (Wenzhou Medical University), Shengnan Zhou (0000-0003-3198-7867, Wenzhou Medical University), Dandan Geng (0000-0001-6724-5609, First Affiliated Hospital of Wenzhou Medical University), Lin Cheng (0000-0002-0837-9129, First Affiliated Hospital of Wenzhou Medical University), Kaili Fan (0000-0002-8723-7902, Wenzhou Medical University), Xin Yu (0000-0003-3983-4937, Wenzhou Medical University, corresponding author), Wenjie Tang (0000-0003-3322-4804, First Affiliated Hospital of Wenzhou Medical University, corresponding author), Jincai He (0000-0002-1211-6882, Wenzhou Medical University, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 556981-556981 |
| Publication date | 2021-06-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.556981 |
| PMID | 34248685 |
| OpenAlex | W3174468918 |
| Language | EN |
| Citations received | 2 |
| References cited | 1 |
Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment. Methods: Four hundred thirty-six patients who met the criteria were included in this study from October 2013 to February 2015. The follow-up time for each patient was ~5 years, with follow-up every 3 months. Patients received questionnaires including the 17-item Hamilton Depression Scale (HAMD), the Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel Index (BI). Results: Of the 436 patients, 154 (35.3%) patients with the prevalence of PSD status at baseline, 26 (7.2%) patients with the prevalence of PSD status, and 73 (20.1%) had an unfavorable outcome 5 years after stroke. The odds ratio (OR) for unfavorable outcome at 5 years in the PSD group was ~2.2 relative to the non-PSD group after adjusting for potential risk factors [OR = 2.217, 95% confidence interval (CI) = 1.179-4.421, P = 0.015]. In the early-onset PSD group, HAMD scores were independently associated with 5-year unfavorable outcome rates (OR = 1.168, 95% CI = 1.015-1.345, P = 0.031). Conclusions: Our findings indicate that early-onset PSD status in Chinese patients is an independent risk factor for unfavorable outcome 5 years after stroke, and that the severity of PSD is also related to unfavorable outcome
Activities of daily living · Confidence interval · Depression (economics · Hamd · Ischemic stroke · Modified Rankin Scale · Odds ratio · Physical therapy · Post-stroke depression · Prospective cohort study · Risk factor · Significant difference · Stroke (engine · Acute Ischemic Stroke Management · Dementia and Cognitive Impairment Research · Medicine · Stroke Rehabilitation and Recovery · Internal Medicine
| Unique citing works | 2 |
|---|---|
| Citations per year | 1 |
| Citation span | 2024 - 2025 (2) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |