Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the Covid-19 Lockdown

Bibliographic Data

ID15525344
AuthorsRoberta Baschi (0000-0003-2755-7207, University of Palermo), Antonina Luca (0000-0002-8397-3478, University of Catania), Alessandra Nicoletti (0000-0001-6757-340X, University of Catania), M L Caccamo (0000-0001-9805-5074, University of Palermo), Maria Caccamo, Calogero Edoardo Cicero (0000-0002-8647-8851, University of Catania), Concetta D’Agate (University of Catania), Concetta D'Agate, Lucia Di Giorgi (0009-0007-1687-6401, University of Palermo), Giuseppe La Bianca (University of Palermo), Tiziana Lo Castro (University of Catania), Mario Zappia (0000-0002-8298-9486, University of Catania), Roberto Monastero (0000-0002-2829-523X, University of Palermo, corresponding author)
Year2020
Volume11
Pages590134-590134
Publication date2020-12-14
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.590134
PMID33381057
OpenAlexW3113179649
LanguageEN
Citations received3
References cited35

Objective: The effects of the COVID-19 lockdown on subjects with prodromal phases of dementia are unknown. The aim of this study was to evaluate the motor, cognitive, and behavioral changes during the COVID-19 lockdown in Italy in patients with Parkinson's disease (PD) with and without mild cognitive impairment (PD-MCI and PD-NC) and in patients with MCI not associated with PD (MCInoPD). Methods: A total of 34 patients with PD-NC, 31 PD-MCI, and 31 MCInoPD and their caregivers were interviewed 10 weeks after the COVID-19 lockdown in Italy, and changes in cognitive, behavioral, and motor symptoms were examined. Modified standardized scales, including the Neuropsychiatric Inventory (NPI) and the Movement Disorder Society, Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts I and II, were administered. Multivariate logistic regression was used to evaluate associated covariates by comparing PD-NC vs. PD-MCI and MCInoPD vs. PD-MCI. Results: All groups showed a worsening of cognitive (39.6%), pre-existing (37.5%), and new (26%) behavioral symptoms, and motor symptoms (35.4%) during the COVID-19 lockdown, resulting in an increased caregiver burden in 26% of cases. After multivariate analysis, PD-MCI was significantly and positively associated with the IADL lost during quarantine (OR 3.9, CI 1.61-9.58), when compared to PD-NC. In the analysis of MCInoPD vs. PD-MCI, the latter showed a statistically significant worsening of motor symptoms than MCInoPD (OR 7.4, CI 1.09-45.44). Regarding NPI items, nighttime behaviors statistically differed in MCInoPD vs. PD-MCI (16.1% vs. 48.4%, p = 0.007). MDS-UPDRS parts I and II revealed that PD-MCI showed a significantly higher frequency of cognitive impairment ( p = 0.034), fatigue ( p = 0.036), and speech ( p = 0.013) than PD-NC. On the contrary, PD-MCI showed significantly higher frequencies in several MDS-UPDRS items compared to MCInoPD, particularly regarding pain ( p = 0.001), turning in bed (p = 0.006), getting out of bed ( p = 0.001), and walking and balance ( p = 0.003). Conclusion: The COVID-19 quarantine is associated with the worsening of cognitive, behavioral, and motor symptoms in subjects with PD and MCI, particularly in PD-MCI. There is a need to implement specific strategies to contain the effects of quarantine in patients with PD and cognitive impairment and their caregivers

Clinical Dementia Rating · Cognition · Coronavirus disease 2019 (COVID-19 · Dementia · Developmental psychology · Disease · Logistic regression · Movement Disorders · Multivariate analysis · Parkinson's disease · Psychiatry · Rating scale · Dementia and Cognitive Impairment Research · Long-Term Effects of COVID-19 · Medicine · Parkinson's Disease Mechanisms and Treatments · Psychology · Internal Medicine

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