Effect of DL-Methylephedrine on Dopamine Transporter Using Positron Emission Tomography With [18F]FE-PE2I
Bibliographic Data
| ID | 15525468 |
|---|---|
| Authors | Tsuyoshi Nogami (Nippon Medical School), Ryosuke Arakawa (0000-0001-5569-1361, Nippon Medical School), Takeshi Sakayori (Nippon Medical School), Yumiko Ikeda (Nippon Medical School), Yoshiro Okubo (0000-0003-1767-0230, Nippon Medical School), Amane Tateno (0000-0002-4590-0120, Nippon Medical School, corresponding author) |
| Year | 2022 |
| Volume | 13 |
| Pages | 799319-799319 |
| Publication date | 2022-05-31 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.799319 |
| PMID | 35711596 |
| OpenAlex | W4281889926 |
| Language | EN |
| References cited | 38 |
In this study, the urinary concentration of dl-methylephedrine (13.9 μg/mL) was higher than the prohibited reference value (10.0 μg/mL), and there was no significant difference in DAT occupancy between dl-methylephedrine and placebo. These findings suggest that a clinical daily dose of dl-methylephedrine may exceed the doping regulation value according to urine concentration; however, it was considered that at least the central excitatory effect mediated by DAT inhibition was not observed at the daily dose of dl-methylephedrine
Ephedrine · Nuclear medicine · Pathology · Placebo · Positron emission tomography · Chemistry · Forensic Toxicology and Drug Analysis · Hormonal and reproductive studies · Medical Imaging Techniques and Applications · Medicine · Endocrinology · Internal Medicine · Pharmacology
| Highly cited | No |
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