Associations of physical activity participation trajectories with subsequent motor function declines and incident frailty

In addition to persistent PA, increasing PA was linked to a slower decline in motor function and lower risk of incident frailty in the cohort. Our findings suggest that regular PA is never too late

Cohort · Cohort study · Confidence interval · Environmental health · Grip strength · Hazard ratio · Longitudinal study · Physical medicine and rehabilitation · Physical therapy · Population · Proportional hazards model · Quality of life (healthcare · Demography · Frailty in Older Adults · Health disparities and outcomes · Medicine · Nutrition and Health in Aging · Gerontology · Internal Medicine

• Assessing frailty in older adults

  Open Access•Mert Doğan, Özge Erol Doğan et al.•Frontiers in Public Health•2025

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• What are the Modifiable Risk Factors for Later Life Frailty Development Found Within Midlife Community-Dwelling Adults? A Systematic Review

  Open Access•Sophie Longworth, Barnabas Panayiotou•Journal of Aging and Health•2026

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• Group-Based Trajectory Modeling

  Open Access•Daniel S Nagin•Annals of Nutrition and Metabolism•2014

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• Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults

  Marco Pahor, Jack M Guralnik et al.•JAMA•2014

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• Frailty

  Open Access•Emiel O Hoogendijk, Jonathan Afilalo et al.•The Lancet•2019

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• Sarcopenia

  Open Access•Alfonso J Cruz‐Jentoft, Alfonso J Cruz-Jentoft et al.•Age and Ageing•2010

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• Frailty in elderly people

  Open Access•Andrew Clegg, John Young et al.•The Lancet•2013

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• Compendium of Physical Activities

  Barbara E Ainsworth, William L Haskell et al.•Medicine & Science in Sports &…•2011

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• A standard procedure for creating a frailty index

  Open Access•Samuel D Searle, Arnold Mitnitski et al.•BMC Geriatrics•2008

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• A review of the measurement of grip strength in clinical and epidemiological studies

  Helen C Roberts, Hayley J Denison et al.•Age and Ageing•2011

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• Health, functioning, and disability in older adults—present status and future implications

  Open Access•Somnath Chatterji, Julie Byles et al.•The Lancet•2015

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• Cohort Profile

  Open Access•Andrew Steptoe, Elizabeth Breeze et al.•International Journal of…•2013

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• Frailty in Older Adults

  Linda P Fried, Catherine M Tangen et al.•The Journals of Gerontology…•2001

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• Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017

  Open Access•L James, Spencer L James et al.•The Lancet•2018

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• Physical activity and trajectories in cognitive function

  Mark Hamer, Graciela Muniz-Terrera et al.•Journal of Epidemiology and…•2018

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• Trajectories of physical activity from midlife to old age and associations with subsequent cardiovascular disease and all-cause mortality

  Open Access•Daniel Aggio, Efstathios Papachristou et al.•Journal of Epidemiology and…•2020

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