Staging, Neurocognition and Social Functioning in Bipolar Disorder
Bibliographic Data
| ID | 15525568 |
|---|---|
| Authors | Amparo Tatay-Manteiga (0000-0002-2029-2683, Hospital General Universitario De Valencia), Patricia Correa‐Ghisays (0000-0002-1752-7349, Universitat de València), Patricia Correa-Ghisays, Omar Cauli (0000-0001-5669-4943, Universitat de València), Flávio Kapczinski (0000-0001-8738-856X, McMaster University), Flavio P Kapczinski, Rafael Tabarés‐Seisdedos (0000-0002-1089-2204, Universitat de València), Rafael Tabarés-Seisdedos, Vicent Balanzá‐Martínez (0000-0001-7772-7396, Centro de Investigación Biomédica en Red de Salud Mental, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 709-709 |
| Publication date | 2018-12-19 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00709 |
| PMID | 30618879 |
| OpenAlex | W2903706626 |
| Language | EN |
| Citations received | 1 |
| References cited | 51 |
Introduction: Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. The 'latent stage' of BD remains understudied. This cross-sectional study assessed staging, neurocognition and social functioning among BD patients and their healthy siblings. Methods: Four groups were included: euthymic type I BD patients in the early ( n = 25) and late ( n = 23) stages, their healthy siblings (latent stage; n = 23) and healthy controls ( n = 21). All 92 subjects underwent a comprehensive neuropsychological battery of processing speed, verbal learning/memory, visual memory, working memory, verbal fluency, executive cognition, and motor speed. Social functioning was assessed using the FAST scale. Results: Siblings' social functioning was identical to that of controls, and significantly better than both early- ( p p p F = 1.59; p = 0.005). Healthy siblings' performance lied between those of controls and patients, with deficits in tasks of processing speed, executive attention, verbal memory/learning, and visual memory. Both early- and late-stage patients had a more severe and widespread dysfunction than siblings, with no significant differences between them. Conclusions: Genetic vulnerability to BD-I seems to be associated with neurocognitive impairments, whereas social dysfunction would be the result of the clinical phenotype. Staging models of BD should take into account these divergent findings in the latent stage
Audiology · Bipolar disorder · Cognition · Developmental psychology · Effects of sleep deprivation on cognitive performance · Executive functions · Neurocognitive · Neuropsychology · Psychiatry · Verbal fluency test · Verbal learning · Verbal memory · Visual memory · Working memory · Bipolar Disorder and Treatment · Clinical Psychology · Genetics and Neurodevelopmental Disorders · Medicine · Psychology · Schizophrenia research and treatment
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |