Inhibitory Control and Craving in Dual Disorders and Recurrent Substance Use. Preliminary Findings

Bibliographic Data

ID15525580
AuthorsJUDITH C L M BEERTEN-DUIJKERS (0000-0002-2742-4167, Vincent Van Gogh Voor Geestelijke Gezondheidszorg, corresponding author), Constance Th W M Vissers, Constance Vissers (0000-0001-8773-7037, Royal Dutch Kentalis), Mike Rinck (Radboud University Nijmegen), J I M Egger (0000-0002-9311-9013, Vincent Van Gogh Voor Geestelijke Gezondheidszorg)
Year2021
Volume12
Pages569817-569817
Publication date2021-02-03
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.569817
PMID33613336
OpenAlexW3126385941
LanguageEN
Citations received2
References cited46

Objective: In Dual Disorders (DD), which involves the co-occurrence of a disorder in substance use and a mental disorder, recurrent struggles with addictive behavior are frequent. Neuropsychological knowledge concerning the profile of inhibitory control and the irresistible urge to use substances (craving) within the DD patient group may contribute to the prevention of this recurrent addictive behavior. Methods: Inhibitory control and craving were assessed in 25 patients with DD and 25 healthy controls (HC). Inhibitory control tasks (Go/No-go task and Stop Signal Task) were performed combined with brain measurements (Event Related Potentials) mapping inhibitory control. Moreover, implicit and explicit measures concerning craving were administered. Statistical DD and HC comparisons, correlational and regression analyses on exploratory base were conducted. Results: DD patients committed more inhibitory control errors than HC when confronted with (alcohol) consumption-related picture stimuli. Furthermore, patients with DD showed higher levels of implicit and explicit craving. The number of inhibitory control errors was positively related to levels of implicit and explicit craving. Moreover, explicit craving and impulsivity (as a dimension of inhibitory control) predicted the severity of addictive behavior. Event Related Potential analyses did not show differences in inhibitory control-associated brain activity between DD patients and HC; both groups showed reduction of P300 amplitudes in response to alcohol pictures. Conclusions: Impulsivity and craving are elevated in DD patients and show predictive value for the severity of addictive behavior. One's level of impulsive action tendency may trigger less effort to control (recurrent) substance use. The findings may contribute to existing DD treatment indications by the promotion of impulse control training via "stop-think-act" methods for DD patients

Addiction · Association (psychology · Cognition · Craving · Developmental psychology · Impulsivity · Inhibitory control · Inhibitory postsynaptic potential · Neuropsychology · Psychiatry · Psychotherapist · Attention Deficit Hyperactivity Disorder · Clinical Psychology · Neural and Behavioral Psychology Studies · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology

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