Brain causality alterations in major depressive disorder treatment

Bibliographic Data

ID15525583
AuthorsMadhurima Bhattacharjee (Czech Academy of Sciences, corresponding author), Ioannis Vlachos (Czech Academy of Sciences), Aditi Kathpalia (Czech Academy of Sciences), Jaroslav Hlinka (0000-0003-1402-1470, Czech Academy of Sciences), Martin Brunovský (0000-0002-2483-0848, Charles University), Martin Bareš (0000-0003-0181-6311, Charles University), Milan Paluš (0000-0001-8474-1436, Czech Academy of Sciences)
Year2026
Volume16
Pages1718216-1718216
Publication date2026-01-27
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1718216
PMID41675668
OpenAlexW7125773492
LanguageEN
References cited7

Early-phase directional brain connectivity analysis reveals that pharmacological and neurostimulation treatments engage distinct neural oscillatory mechanisms within the first week. Elevated baseline right-dominant α -band causal transmission identifies patients unlikely to respond to pharmacological treatment, enabling alternative interventions before weeks of ineffective therapy. These phase-based causality metrics offer promising biomarkers for early treatment stratification and monitoring. The ability to distinguish treatment responders from nonresponders at baseline and detect treatment-specific changes within one week, before clinical response manifestation, suggests these causality measures capture early mechanistic alterations that could inform timely treatment optimization decisions. (EUDRACT Nos. 2005-000826-22 and 2015-001639-19, registered via www.clinicaltrialsregister.eu)

Baseline (sea · Causality (physics · Clinical trial · Major depressive disorder · Neuroimaging · Neurostimulation · Psychological intervention · Functional Brain Connectivity Studies · Mental Health Research Topics · Neural dynamics and brain function

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