Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype?—A Perspective Paper

Bibliographic Data

ID15525705
AuthorsLars V Kessing (0000-0001-9377-9436, Copenhagen University Hospital, corresponding author), Kamilla W Miskowiak (0000-0003-2572-1384, University of Copenhagen), Kamilla Miskowiak
Year2018
Volume9
Pages490-490
Publication date2018-10-08
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2018.00490
PMID30349492
OpenAlexW2897995580
LanguageEN
Citations received1
References cited70

The present perspective paper addresses and discusses whether cognitive dysfunction in bipolar disorder qualifies as a diagnostic intermediate phenotype using the Robin and Guze criteria of diagnostic validity. The paper reviews current data within (1) delineation of the clinical intermediate phenotype, (2) associations of the intermediate phenotype with para-clinical data such as brain imaging and blood-based data, (3) associations to family history / genetics, (4) characteristics during long-term follow-up, and (5) treatment effects on cognition. In this way, the paper identifies knowledge gaps and suggests recommendations for future research within each of the five areas. Based on the current state of knowledge, we conclude that cognitive dysfunction does not qualify as a diagnostic intermediate phenotype or endophenotype for bipolar disorder, although promising new evidence points to emotion and reward processing abnormalities as possible putative endophenotypes

Biology · Bipolar disorder · Clinical phenotype · Cognition · Cognitive psychology · Endophenotype · Perspective (graphical · Phenotype · Adolescent and Pediatric Healthcare · Bipolar Disorder and Treatment · Clinical Psychology · Computer Science · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment · Genetics

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