Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch)

Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample

Bibliographic Data

ID15525950
AuthorsUmut Kırlı (0000-0001-9924-2672, Maastricht University Medical Centre, corresponding author), Tolga Binbay (0000-0001-6030-6798, Dokuz Eylül University), Hayriye Elbi (0000-0003-3651-4292, Ege University), Marjan Drukker (0000-0002-6346-2662, Maastricht University Medical Centre), Bülent Kayahan (Ege University), Ferda Özkınay (0000-0001-7542-7787, Ege University), Hüseyin Önay (0000-0002-0584-8866, Ege University), Köksal Alptekın (Dokuz Eylül University), Köksal Alptekin, Jim Van Os (0000-0002-7245-1586, Maastricht University Medical Centre)
Year2019
Volume10
Pages554-554
Publication date2019-08-07
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2019.00554
PMID31447712
OpenAlexW2961005333
LanguageEN
Citations received1
References cited72

Objective: TürkSch is a prospective, longitudinal study in a representative community sample (İzmir, Turkey), consisting of several data collection stages, to screen and follow-up mental health outcomes, with a special focus on the extended and transdiagnostic psychosis phenotype. The aim of the present paper is to describe the research methodology, data collection results, and associations with noncontact and refusal in the longitudinal arm. Methods: Households were contacted in a multistage clustered probability sampling frame, covering 11 districts and 302 neighborhoods at baseline (n = 4,011) and at 6-year follow-up (n = 2,185). Both at baseline and at follow-up, participants were interviewed with the Composite International Diagnostic Interview. Participants with probable psychotic disorder were reinterviewed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID)-I either at the hospital or at the participant's residence. Relevant neighborhood-level measures were assessed in a separate sample (n = 5,124) in addition to individual-level measures. Candidate gene-by-environment interactions were investigated using two nested case-control studies. Results: Individuals with a mental health problem had lower refusal rates. Older and lower educated individuals had a lower probability of noncontact. Discussion: The TürkSch study has an advanced design to meet the challenges of evaluating the multidimensional etiological and phenomenological nature of the extended and transdiagnostic psychosis phenotype

Attrition · Biology · Cohort · Gene · Mental health · Phenotype · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Autism Spectrum Disorder Research · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Medicine · Obsessive-Compulsive Spectrum Disorders · Psychology · Genetics · Internal Medicine

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