High-intensity transcranial alternating current stimulation combined with pharmacotherapy for adolescent major depressive disorder

A prospective case report study

Bibliographic Data

ID15525965
AuthorsZiyi Yuan (0009-0003-5787-7276), Z Z Yuan (Chongqing City Mental Health Center), Ying Hu (0000-0002-9875-1077, Chongqing City Mental Health Center), Dandan Cheng (0000-0003-2560-177X, The Affiliated Yongchuan Hospital of Chongqing Medical University), Yilin Yang (0000-0001-8169-5470, The Affiliated Yongchuan Hospital of Chongqing Medical University), Hong Su (0000-0002-4673-6449, The Affiliated Yongchuan Hospital of Chongqing Medical University, corresponding author), Su Hong (0000-0003-2294-5251), Li Kuang (0000-0002-3265-2252, The Affiliated Yongchuan Hospital of Chongqing Medical University, corresponding author)
Year2025
Volume16
Pages1664698-1664698
Publication date2025-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1664698
PMID41103740
OpenAlexW4414710430
LanguageEN
References cited34

The combination of HI-tACS and pharmacotherapy demonstrated potential early effects in this small cohort of adolescents with MDD, particularly during the initial phase of treatment. These preliminary findings warrant further investigation through large-scale randomized controlled trials to establish efficacy and safety profiles, and to further characterize suicide risk trajectories

Depression (economics · Depressive symptoms · Major depressive disorder · Major depressive episode · Pharmacotherapy · Prospective cohort study · Randomized controlled trial · Transcranial Direct Current Stimulation · Transcranial magnetic stimulation · Functional Brain Connectivity Studies · Neural and Behavioral Psychology Studies · Transcranial Magnetic Stimulation Studies

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Open DOIOpen Access