Descended Social Anxiety Disorder and Craving in Women Heroin Dependence Through Exercise Alerts Plasma Oxytocin Levels

Bibliographic Data

ID15526166
AuthorsJingsong Wang (0000-0001-5002-2636, Hunan Normal University), Jing Song Wang, Jing Lin Liu (Hunan Normal University), Jun Zhang (0000-0003-1706-1611, Hunan Police Academy), Jun Tan (0000-0002-0288-2487, Hunan International Economics University), Ting Huang (0000-0003-4186-8714, Hunan Normal University), Chun Xia Lu (Hunan Normal University), Xi Peng (0000-0001-8285-2757, Hunan Normal University), Xi Yang Peng, Yin Guo (0009-0008-3306-1404, Hunan Normal University, corresponding author), Lan Zheng (0000-0001-7789-0185, Hunan Normal University, corresponding author)
Year2021
Volume12
Pages624993-624993
Publication date2021-11-26
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.624993
PMID34899404
OpenAlexW3217249755
LanguageEN
Citations received3
References cited42

Purpose: This study explored the association between peripheral blood oxytocin (OT) and social anxiety disorder (SAD) and cue-induced cravings in female heroin addicts. The effect of exercise on alleviation of SAD and OT levels was also explored. Methods: A total of 72 females with heroin dependence were assigned to three groups based on SAD severity. The three groups were Non-SAD control, SAD control, and SAD exercise groups. Subjects in the SAD exercise group underwent aerobic exercise and resistance training for 8 weeks (60 min/day, 5 days/week). Enzyme-linked immunosorbent assay analysis and Liebowitz Social Anxiety Scale (LSAS) scores were used to determine plasma OT concentration and SAD, respectively. Cue-induced craving was assessed using Visual Analog Scale (VAS) and Desires for Drug Questionnaire (DDQ). Mixed-effect analysis of variance and Pearson correlation analysis were used to explore the effect and correlation between different parameters. Results: OT levels in the SAD exercise group were significantly high after exercise ( p p r = -0.534, p r = -0.609, p r = -0.555, p r = -0.332, p r = 0.258, p r = 0.588, p r = 0.282, p Conclusions: The findings of the present study indicate that plasma OT is a potential peripheral biomarker for prediction of the severity of social anxiety in female heroin withdrawal patients. Aerobic exercise combined with resistance training plus incremental load for 8 weeks can increase plasma OT levels and significantly reduce severity of SAD and cue-induced cravings in female heroin addicts

Addiction · Analysis of variance · Anxiety · Craving · Drug · Heroin · Oxytocin · Physical therapy · Psychiatry · Social anxiety · Visual analogue scale · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Child and Adolescent Psychosocial and Emotional Development · Medicine · Neuroendocrine regulation and behavior · Psychology · Internal Medicine

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